| pubmed-article:10616207 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10616207 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:10616207 | lifeskim:mentions | umls-concept:C0431085 | lld:lifeskim |
| pubmed-article:10616207 | lifeskim:mentions | umls-concept:C0148199 | lld:lifeskim |
| pubmed-article:10616207 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:10616207 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:10616207 | lifeskim:mentions | umls-concept:C0237881 | lld:lifeskim |
| pubmed-article:10616207 | lifeskim:mentions | umls-concept:C0750502 | lld:lifeskim |
| pubmed-article:10616207 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:10616207 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:10616207 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:10616207 | pubmed:dateCreated | 2000-1-13 | lld:pubmed |
| pubmed-article:10616207 | pubmed:abstractText | Vascular endothelial growth factor (VEGF) is one of the key factors in tumor neoangiogenesis, acting through its receptors KDR (VEGFR-2) and fit-1 (VEGFR-1) expressed on endothelial cells. Our data demonstrate that VEGFR-1 and to a lesser extent VEGFR-2 are expressed in a number of human tumor tissues and derived cells in culture. VEGFR-1 protein is expressed in 26 of 42 glioma tissues, 22 of which show a coexpression of VEGFR-1 with VEGFR-2; 1 glioma tissue expresses exclusively VEGFR-2. In the derived glioma cell cultures, we found VEGFR-1 mRNA expression in 6 of 11 cultures, with one coexpressing VEGFR-1 and VEGFR-2. Of four established glioma cell lines, two expressed VEGFR-1. In addition VEGFR-1 protein expression was demonstrated in 30 of 37 tumor tissues of squamous cell carcinomas of the head and neck, with VEGFR-2 coexpression in 15 tissues and an expression of VEGFR-2 alone in 1 tissue. Derived tumor cell cultures showed mRNA expression of VEGFR-1 alone in seven of seven cases. Established melanoma cell lines expressed VEGFR-1 mRNA in four of five lines, with VEGFR-2 coexpression in two lines. Concerning the functional significance of VEGF receptor expression, VEGF treatment of VEGFR-1-expressing tumor cells induced the inhibition of cell proliferation by 25 to 55% and the inhibition of tumor cell migration by 29 to 55%. Thus our data indicate that the coexpression of VEGF and VEGFR-1 in tumor cells could have an inhibitory effect on tumor cell proliferation and migration, a mechanism possibly induced as a response to a deficiency in nutrient and oxygen supply. | lld:pubmed |
| pubmed-article:10616207 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10616207 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10616207 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10616207 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10616207 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10616207 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10616207 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10616207 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10616207 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10616207 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10616207 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10616207 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10616207 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:10616207 | pubmed:issn | 0023-6837 | lld:pubmed |
| pubmed-article:10616207 | pubmed:author | pubmed-author:FusenigN ENE | lld:pubmed |
| pubmed-article:10616207 | pubmed:author | pubmed-author:AndoYY | lld:pubmed |
| pubmed-article:10616207 | pubmed:author | pubmed-author:RiedeDD | lld:pubmed |
| pubmed-article:10616207 | pubmed:author | pubmed-author:MuellerM MMM | lld:pubmed |
| pubmed-article:10616207 | pubmed:author | pubmed-author:ReisserCC | lld:pubmed |
| pubmed-article:10616207 | pubmed:author | pubmed-author:SteinerH HHH | lld:pubmed |
| pubmed-article:10616207 | pubmed:author | pubmed-author:ButtlerAA | lld:pubmed |
| pubmed-article:10616207 | pubmed:author | pubmed-author:Herold-MendeC... | lld:pubmed |
| pubmed-article:10616207 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10616207 | pubmed:volume | 79 | lld:pubmed |
| pubmed-article:10616207 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10616207 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10616207 | pubmed:pagination | 1573-82 | lld:pubmed |
| pubmed-article:10616207 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:10616207 | pubmed:meshHeading | pubmed-meshheading:10616207... | lld:pubmed |
| pubmed-article:10616207 | pubmed:meshHeading | pubmed-meshheading:10616207... | lld:pubmed |
| pubmed-article:10616207 | pubmed:meshHeading | pubmed-meshheading:10616207... | lld:pubmed |
| pubmed-article:10616207 | pubmed:meshHeading | pubmed-meshheading:10616207... | lld:pubmed |
| pubmed-article:10616207 | pubmed:meshHeading | pubmed-meshheading:10616207... | lld:pubmed |
| pubmed-article:10616207 | pubmed:meshHeading | pubmed-meshheading:10616207... | lld:pubmed |
| pubmed-article:10616207 | pubmed:meshHeading | pubmed-meshheading:10616207... | lld:pubmed |
| pubmed-article:10616207 | pubmed:meshHeading | pubmed-meshheading:10616207... | lld:pubmed |
| pubmed-article:10616207 | pubmed:meshHeading | pubmed-meshheading:10616207... | lld:pubmed |
| pubmed-article:10616207 | pubmed:meshHeading | pubmed-meshheading:10616207... | lld:pubmed |
| pubmed-article:10616207 | pubmed:meshHeading | pubmed-meshheading:10616207... | lld:pubmed |
| pubmed-article:10616207 | pubmed:meshHeading | pubmed-meshheading:10616207... | lld:pubmed |
| pubmed-article:10616207 | pubmed:meshHeading | pubmed-meshheading:10616207... | lld:pubmed |
| pubmed-article:10616207 | pubmed:meshHeading | pubmed-meshheading:10616207... | lld:pubmed |
| pubmed-article:10616207 | pubmed:meshHeading | pubmed-meshheading:10616207... | lld:pubmed |
| pubmed-article:10616207 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10616207 | pubmed:articleTitle | Expression and functional significance of vascular endothelial growth factor receptors in human tumor cells. | lld:pubmed |
| pubmed-article:10616207 | pubmed:affiliation | Department of Neurosurgery, University of Heidelberg, Germany. Christel_Herold-Mende@med.uni-heidelberg.de | lld:pubmed |
| pubmed-article:10616207 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10616207 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10616207 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10616207 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10616207 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10616207 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10616207 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10616207 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10616207 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10616207 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10616207 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10616207 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10616207 | lld:pubmed |
