| pubmed-article:10611638 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10611638 | lifeskim:mentions | umls-concept:C0028040 | lld:lifeskim |
| pubmed-article:10611638 | lifeskim:mentions | umls-concept:C0521119 | lld:lifeskim |
| pubmed-article:10611638 | lifeskim:mentions | umls-concept:C0028633 | lld:lifeskim |
| pubmed-article:10611638 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:10611638 | lifeskim:mentions | umls-concept:C0220839 | lld:lifeskim |
| pubmed-article:10611638 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:10611638 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:10611638 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:10611638 | pubmed:dateCreated | 2000-2-17 | lld:pubmed |
| pubmed-article:10611638 | pubmed:abstractText | In the present study, we have characterized the neuropharmacological regulation of nicotine-induced increases in extracellular nucleus accumbens glutamate levels. Sprague-Dawley rats were stereotaxically implanted with 2 mm microdialysis probes in the nucleus accumbens and on the following day in vivo microdialysis experiments were performed in awake, freely moving animals. An acute dose of nicotine (0.3-0.6 mg/kg, s.c.) produced an increase in nucleus accumbens glutamate levels with a maximal increase of approximately 50% following the higher dose. No changes in nucleus accumbens aspartate levels were found. The increase in glutamate levels following nicotine (0.3 mg/kg, s.c.) was blocked by mecamylamine (1 mg/kg, i.p. ) but not by haloperidol (0.2 mg/kg, i.p.) pretreatment. Local perfusion of artificial cerebrospinal fluid (CSF) without calcium did not alter nicotine (0.3 mg/kg, s.c.) stimulation of glutamate levels. Local perfusion with a selective blocker for the GLT-1 glutamate transporter, dihydrokainic acid (DHKA) (10(-4) M), had no effect, while local perfusion with a nonselective glutamate transporter blocker, L-trans-pyrrolidine-2,4-dicarboxylic acid (PDC) (10(-4) M), blocked nicotine (0.3 mg/kg, s.c.) stimulation of glutamate levels. In animals previously dopamine denervated by local injections of 6-hydroxydopamine (6-OHDA) into the nucleus accumbens, nicotine (0.3 mg/kg, s.c.) stimulation of glutamate levels was enhanced vs. sham-lesioned animals. These findings demonstrate a novel form of nucleus accumbens glutamate release that is dopamine- and calcium-independent. The ability of PDC to block the effects of nicotine suggest that a glutamate transporter may be involved in mediating the stimulation of glutamate release. | lld:pubmed |
| pubmed-article:10611638 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10611638 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10611638 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10611638 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10611638 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10611638 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10611638 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10611638 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10611638 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10611638 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:10611638 | pubmed:issn | 0887-4476 | lld:pubmed |
| pubmed-article:10611638 | pubmed:author | pubmed-author:FoxLL | lld:pubmed |
| pubmed-article:10611638 | pubmed:author | pubmed-author:ReidM SMS | lld:pubmed |
| pubmed-article:10611638 | pubmed:author | pubmed-author:BergerS PSP | lld:pubmed |
| pubmed-article:10611638 | pubmed:author | pubmed-author:HoL BLB | lld:pubmed |
| pubmed-article:10611638 | pubmed:copyrightInfo | Copyright 2000 Wiley-Liss, Inc. | lld:pubmed |
| pubmed-article:10611638 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10611638 | pubmed:volume | 35 | lld:pubmed |
| pubmed-article:10611638 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10611638 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10611638 | pubmed:pagination | 129-36 | lld:pubmed |
| pubmed-article:10611638 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:10611638 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10611638 | pubmed:articleTitle | Nicotine stimulation of extracellular glutamate levels in the nucleus accumbens: neuropharmacological characterization. | lld:pubmed |
| pubmed-article:10611638 | pubmed:affiliation | New York University, Department of Psychiatry, Veteran's Affairs Medical Center, New York, New York, USA. REID.MALCOLM_S+@NEW-YORK.VA.GOV | lld:pubmed |
| pubmed-article:10611638 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10611638 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10611638 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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