| pubmed-article:10611351 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10611351 | lifeskim:mentions | umls-concept:C0033164 | lld:lifeskim |
| pubmed-article:10611351 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:10611351 | lifeskim:mentions | umls-concept:C0085209 | lld:lifeskim |
| pubmed-article:10611351 | lifeskim:mentions | umls-concept:C1521797 | lld:lifeskim |
| pubmed-article:10611351 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:10611351 | pubmed:issue | 26 | lld:pubmed |
| pubmed-article:10611351 | pubmed:dateCreated | 2000-1-27 | lld:pubmed |
| pubmed-article:10611351 | pubmed:abstractText | There is growing concern that bovine spongiform encephalopathy (BSE) may have passed from cattle to humans. We report here that transgenic (Tg) mice expressing bovine (Bo) prion protein (PrP) serially propagate BSE prions and that there is no species barrier for transmission from cattle to Tg(BoPrP) mice. These same mice were also highly susceptible to a new variant of Creutzfeldt-Jakob disease (nvCJD) and natural sheep scrapie. The incubation times (approximately 250 days), neuropathology, and disease-causing PrP isoforms in Tg(BoPrP)Prnp(0/0) mice inoculated with nvCJD and BSE brain extracts were indistinguishable and differed dramatically from those seen in these mice injected with natural scrapie prions. Our findings provide the most compelling evidence to date that prions from cattle with BSE have infected humans and caused fatal neurodegeneration. | lld:pubmed |
| pubmed-article:10611351 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10611351 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10611351 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10611351 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10611351 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10611351 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10611351 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10611351 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10611351 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10611351 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10611351 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10611351 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10611351 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10611351 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10611351 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10611351 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10611351 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10611351 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10611351 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10611351 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10611351 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10611351 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10611351 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10611351 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10611351 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10611351 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10611351 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10611351 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10611351 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10611351 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10611351 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10611351 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10611351 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10611351 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10611351 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10611351 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10611351 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10611351 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10611351 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10611351 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10611351 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10611351 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10611351 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10611351 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10611351 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10611351 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10611351 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10611351 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10611351 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10611351 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10611351 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10611351 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10611351 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:10611351 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:10611351 | pubmed:author | pubmed-author:PrusinerS BSB | lld:pubmed |
| pubmed-article:10611351 | pubmed:author | pubmed-author:WillRR | lld:pubmed |
| pubmed-article:10611351 | pubmed:author | pubmed-author:IronsideJJ | lld:pubmed |
| pubmed-article:10611351 | pubmed:author | pubmed-author:ScottM RMR | lld:pubmed |
| pubmed-article:10611351 | pubmed:author | pubmed-author:DeArmondS JSJ | lld:pubmed |
| pubmed-article:10611351 | pubmed:author | pubmed-author:TremblayPP | lld:pubmed |
| pubmed-article:10611351 | pubmed:author | pubmed-author:NguyenH OHO | lld:pubmed |
| pubmed-article:10611351 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10611351 | pubmed:day | 21 | lld:pubmed |
| pubmed-article:10611351 | pubmed:volume | 96 | lld:pubmed |
| pubmed-article:10611351 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10611351 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10611351 | pubmed:pagination | 15137-42 | lld:pubmed |
| pubmed-article:10611351 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:10611351 | pubmed:meshHeading | pubmed-meshheading:10611351... | lld:pubmed |
| pubmed-article:10611351 | pubmed:meshHeading | pubmed-meshheading:10611351... | lld:pubmed |
| pubmed-article:10611351 | pubmed:meshHeading | pubmed-meshheading:10611351... | lld:pubmed |
| pubmed-article:10611351 | pubmed:meshHeading | pubmed-meshheading:10611351... | lld:pubmed |
| pubmed-article:10611351 | pubmed:meshHeading | pubmed-meshheading:10611351... | lld:pubmed |
| pubmed-article:10611351 | pubmed:meshHeading | pubmed-meshheading:10611351... | lld:pubmed |
| pubmed-article:10611351 | pubmed:meshHeading | pubmed-meshheading:10611351... | lld:pubmed |
| pubmed-article:10611351 | pubmed:meshHeading | pubmed-meshheading:10611351... | lld:pubmed |
| pubmed-article:10611351 | pubmed:meshHeading | pubmed-meshheading:10611351... | lld:pubmed |
| pubmed-article:10611351 | pubmed:meshHeading | pubmed-meshheading:10611351... | lld:pubmed |
| pubmed-article:10611351 | pubmed:meshHeading | pubmed-meshheading:10611351... | lld:pubmed |
| pubmed-article:10611351 | pubmed:meshHeading | pubmed-meshheading:10611351... | lld:pubmed |
| pubmed-article:10611351 | pubmed:meshHeading | pubmed-meshheading:10611351... | lld:pubmed |
| pubmed-article:10611351 | pubmed:meshHeading | pubmed-meshheading:10611351... | lld:pubmed |
| pubmed-article:10611351 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10611351 | pubmed:articleTitle | Compelling transgenetic evidence for transmission of bovine spongiform encephalopathy prions to humans. | lld:pubmed |
| pubmed-article:10611351 | pubmed:affiliation | Institute for Neurodegenerative Diseases, University of California, San Francisco, CA 94143, USA. | lld:pubmed |
| pubmed-article:10611351 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10611351 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10611351 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10611351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10611351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10611351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10611351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10611351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10611351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10611351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10611351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10611351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10611351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10611351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10611351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10611351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10611351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10611351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10611351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10611351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10611351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10611351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10611351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10611351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10611351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10611351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10611351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10611351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10611351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10611351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10611351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10611351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10611351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10611351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10611351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10611351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10611351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10611351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10611351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10611351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10611351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10611351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10611351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10611351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10611351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10611351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10611351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10611351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10611351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10611351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10611351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10611351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10611351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10611351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10611351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10611351 | lld:pubmed |
