| pubmed-article:10604738 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10604738 | lifeskim:mentions | umls-concept:C0032854 | lld:lifeskim |
| pubmed-article:10604738 | lifeskim:mentions | umls-concept:C0042172 | lld:lifeskim |
| pubmed-article:10604738 | lifeskim:mentions | umls-concept:C0105770 | lld:lifeskim |
| pubmed-article:10604738 | lifeskim:mentions | umls-concept:C0205287 | lld:lifeskim |
| pubmed-article:10604738 | lifeskim:mentions | umls-concept:C0521449 | lld:lifeskim |
| pubmed-article:10604738 | lifeskim:mentions | umls-concept:C0024623 | lld:lifeskim |
| pubmed-article:10604738 | lifeskim:mentions | umls-concept:C0038952 | lld:lifeskim |
| pubmed-article:10604738 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:10604738 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:10604738 | lifeskim:mentions | umls-concept:C0681842 | lld:lifeskim |
| pubmed-article:10604738 | lifeskim:mentions | umls-concept:C0301630 | lld:lifeskim |
| pubmed-article:10604738 | lifeskim:mentions | umls-concept:C1561558 | lld:lifeskim |
| pubmed-article:10604738 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:10604738 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:10604738 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:10604738 | pubmed:dateCreated | 2000-1-3 | lld:pubmed |
| pubmed-article:10604738 | pubmed:abstractText | beta-catenin, a component of the E-cadherin-catenin cell adhesion complex, also plays a separate intracellular signalling role, interacting with APC protein. Intracellular accumulation of beta-catenin is common in colorectal neoplasia. beta-catenin abnormalities are associated with poor survival in gastric cancer, but previous studies do not differentiate between membrane-associated and intracellular beta-catenin. In this study we aimed to determine which type of expression abnormalities for E-cadherin, beta-catenin and alpha-catenin correlate with clinico-pathological features and survival in gastric cancer. Immunoperoxidase staining of paraffin-embedded sections from 40 gastric cancers was performed for E-cadherin, alpha- and beta-catenins using microwave unmasking and an avidin-biotin technique. Clinical data were obtained from case records and cancer registry records. Reduced membranous expression of beta-catenin occurred in 10/12 (83%) diffuse and 8/28 (29%) intestinal tumours (P= 0.0014), and was associated with poor differentiation (P= 0.0015) and short survival (P= 0.032), but not with age, sex, tumour size or nodal status. Nuclear expression of beta-catenin was uncommon; cytoplasmic expression was observed in 13/40 cases (33%) but did not correlate with histology, tumour grade or survival. Reduced E-cadherin membrane expression was associated with lymph node metastasis (P= 0.02). Neither E-cadherin or alpha-catenin expression correlated with survival. Reduced membranous expression of beta-catenin predicts poor prognosis in gastric cancer, whilst ectopic intracellular expression is relatively rare. The apparent differences in beta-catenin expression from those found in colon cancer merit further study. | lld:pubmed |
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| pubmed-article:10604738 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10604738 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10604738 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10604738 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10604738 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:10604738 | pubmed:issn | 0007-0920 | lld:pubmed |
| pubmed-article:10604738 | pubmed:author | pubmed-author:RameshSS | lld:pubmed |
| pubmed-article:10604738 | pubmed:author | pubmed-author:NashJJ | lld:pubmed |
| pubmed-article:10604738 | pubmed:author | pubmed-author:McCullochP... | lld:pubmed |
| pubmed-article:10604738 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10604738 | pubmed:volume | 81 | lld:pubmed |
| pubmed-article:10604738 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10604738 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10604738 | pubmed:pagination | 1392-7 | lld:pubmed |
| pubmed-article:10604738 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:10604738 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10604738 | pubmed:articleTitle | Reduction in membranous expression of beta-catenin and increased cytoplasmic E-cadherin expression predict poor survival in gastric cancer. | lld:pubmed |
| pubmed-article:10604738 | pubmed:affiliation | Department of Surgery, University of Liverpool, UK. | lld:pubmed |
| pubmed-article:10604738 | pubmed:publicationType | Journal Article | lld:pubmed |
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