| pubmed-article:10602519 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10602519 | lifeskim:mentions | umls-concept:C1275278 | lld:lifeskim |
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| pubmed-article:10602519 | lifeskim:mentions | umls-concept:C1515806 | lld:lifeskim |
| pubmed-article:10602519 | lifeskim:mentions | umls-concept:C0332466 | lld:lifeskim |
| pubmed-article:10602519 | lifeskim:mentions | umls-concept:C1522702 | lld:lifeskim |
| pubmed-article:10602519 | lifeskim:mentions | umls-concept:C1417837 | lld:lifeskim |
| pubmed-article:10602519 | lifeskim:mentions | umls-concept:C1420573 | lld:lifeskim |
| pubmed-article:10602519 | lifeskim:mentions | umls-concept:C0599718 | lld:lifeskim |
| pubmed-article:10602519 | lifeskim:mentions | umls-concept:C0599813 | lld:lifeskim |
| pubmed-article:10602519 | lifeskim:mentions | umls-concept:C0599893 | lld:lifeskim |
| pubmed-article:10602519 | pubmed:issue | 52 | lld:pubmed |
| pubmed-article:10602519 | pubmed:dateCreated | 2000-1-13 | lld:pubmed |
| pubmed-article:10602519 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10602519 | pubmed:abstractText | Although most extraskeletal myxoid chondrosarcomas (EMC) are cytogenetically characterized by the translocation t(9;22)(q22;q12), another subset has recently been identified carrying a t(9;17)(q22;q11). Whereas the t(9;22) is known to result in fusion of the CHN (TEC) gene from 9q22 with the EWS gene from 22q12, creating a chimeric EWS/CHN, the genes involved in the t(9;17) of EMC are unknown. We examined two EMC with t(9;17)(q22;q11) and found that the CHN gene was recombined with the RBP56 gene from 17q11 to generate a chimeric RBP56/CHN. RBP56 has not previously been shown to be involved in tumorigenesis but it encodes a putative RNA-binding protein similar to the EWS and FUS (TLS) proteins known to play a pathogenetic role in several sarcomas. The presence of the RBP56/CHN chimeric gene in EMC with t(9;17)(q22;q11) shows that the N-terminal parts of EWS and RBP56 have similar oncogenic potential making them pathogenetically equivalent in oncoproteins arising from fusions with certain transcription factors. | lld:pubmed |
| pubmed-article:10602519 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10602519 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10602519 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10602519 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10602519 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10602519 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:10602519 | pubmed:issn | 0950-9232 | lld:pubmed |
| pubmed-article:10602519 | pubmed:author | pubmed-author:MandahlNN | lld:pubmed |
| pubmed-article:10602519 | pubmed:author | pubmed-author:MertensFF | lld:pubmed |
| pubmed-article:10602519 | pubmed:author | pubmed-author:HeinPP | lld:pubmed |
| pubmed-article:10602519 | pubmed:author | pubmed-author:BjerkehagenBB | lld:pubmed |
| pubmed-article:10602519 | pubmed:author | pubmed-author:SaeterGG | lld:pubmed |
| pubmed-article:10602519 | pubmed:author | pubmed-author:DietrichC UCU | lld:pubmed |
| pubmed-article:10602519 | pubmed:author | pubmed-author:PanagopoulosI... | lld:pubmed |
| pubmed-article:10602519 | pubmed:author | pubmed-author:MencingerMM | lld:pubmed |
| pubmed-article:10602519 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10602519 | pubmed:day | 9 | lld:pubmed |
| pubmed-article:10602519 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:10602519 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10602519 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10602519 | pubmed:pagination | 7594-8 | lld:pubmed |
| pubmed-article:10602519 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:10602519 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10602519 | pubmed:articleTitle | Fusion of the RBP56 and CHN genes in extraskeletal myxoid chondrosarcomas with translocation t(9;17)(q22;q11). | lld:pubmed |
| pubmed-article:10602519 | pubmed:affiliation | Department of Clinical Genetics, Lund University Hospital, S-221 85 Lund, Sweden. | lld:pubmed |
| pubmed-article:10602519 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10602519 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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