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pubmed-article:10600534pubmed:abstractTextThe effect of long-term hindlimb unloading (2 or 5 week) on the expression of uncoupling protein-3 (UCP3) gene was investigated in rat skeletal muscles. The interaction of hindlimb unloading and thyroid status was also investigated at 2 weeks. Whatever the duration, mechanical unloading induced a similar increase in UCP3 mRNA relative abundance in the slow-twitch soleus (SOL) muscle (+80%, P < 0.05), whereas no effect was observed in the fast-twitch extensor digitorum longus (EDL) muscle. Hypothyroidism down-regulated while hyperthyroidism up-regulated UCP3 mRNA relative abundance in both SOL and EDL muscles, but thyroid status did not prevent the up-regulation of UCP3 induced by 2 weeks of suspension. These data therefore indicate for the first time that long-term hindlimb unloading up-regulates muscle UCP3 gene expression in a muscle-specific manner which is independent of thyroid status.lld:pubmed
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pubmed-article:10600534pubmed:copyrightInfoCopyright 1999 Academic Press.lld:pubmed
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pubmed-article:10600534pubmed:pagination518-22lld:pubmed
pubmed-article:10600534pubmed:dateRevised2008-11-21lld:pubmed
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pubmed-article:10600534pubmed:articleTitleMuscle-specific up-regulation of rat UCP3 mRNA expression by long-term hindlimb unloading.lld:pubmed
pubmed-article:10600534pubmed:affiliationCellulaires et Moléculaires, UMR 5578 CNRS-Université Cl. Bernard Lyon I, 43 Boulevard du 11 Novembre 1918, Villeurbanne, F-69622, France.lld:pubmed
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