pubmed-article:10597469 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:10597469 | lifeskim:mentions | umls-concept:C0597336 | lld:lifeskim |
pubmed-article:10597469 | lifeskim:mentions | umls-concept:C0039593 | lld:lifeskim |
pubmed-article:10597469 | lifeskim:mentions | umls-concept:C1511726 | lld:lifeskim |
pubmed-article:10597469 | lifeskim:mentions | umls-concept:C0032863 | lld:lifeskim |
pubmed-article:10597469 | pubmed:dateCreated | 2000-1-24 | lld:pubmed |
pubmed-article:10597469 | pubmed:abstractText | We investigated the asymptotic power of the likelihood-ratio test for detecting linkage to a quantitative trait locus (QTL) using the data set from the Collaborative Study on the Genetics of Alcoholism (COGA). Assuming a total trait heritability of 50% as determined for the COGA Cz P300 phenotype, we determined the minimum QTL heritability required at each point in the genome to achieve 80% power to detect linkage with a lod of 3.0. We find that there are regions of the genome where it is not possible to detect a QTL of any effect with 80% power, and that the overall minimum detectable QTL heritability for the COGA data is 0.35-0.40. | lld:pubmed |
pubmed-article:10597469 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10597469 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10597469 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10597469 | pubmed:language | eng | lld:pubmed |
pubmed-article:10597469 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10597469 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:10597469 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10597469 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:10597469 | pubmed:issn | 0741-0395 | lld:pubmed |
pubmed-article:10597469 | pubmed:author | pubmed-author:WilliamsJ TJT | lld:pubmed |
pubmed-article:10597469 | pubmed:author | pubmed-author:BlangeroJJ | lld:pubmed |
pubmed-article:10597469 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:10597469 | pubmed:volume | 17 Suppl 1 | lld:pubmed |
pubmed-article:10597469 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:10597469 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:10597469 | pubmed:pagination | S397-402 | lld:pubmed |
pubmed-article:10597469 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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pubmed-article:10597469 | pubmed:year | 1999 | lld:pubmed |
pubmed-article:10597469 | pubmed:articleTitle | Asymptotic power of likelihood-ratio tests for detecting quantitative trait loci using the COGA data. | lld:pubmed |
pubmed-article:10597469 | pubmed:affiliation | Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245-0549, USA. | lld:pubmed |
pubmed-article:10597469 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:10597469 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |