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pubmed-article:10597469pubmed:abstractTextWe investigated the asymptotic power of the likelihood-ratio test for detecting linkage to a quantitative trait locus (QTL) using the data set from the Collaborative Study on the Genetics of Alcoholism (COGA). Assuming a total trait heritability of 50% as determined for the COGA Cz P300 phenotype, we determined the minimum QTL heritability required at each point in the genome to achieve 80% power to detect linkage with a lod of 3.0. We find that there are regions of the genome where it is not possible to detect a QTL of any effect with 80% power, and that the overall minimum detectable QTL heritability for the COGA data is 0.35-0.40.lld:pubmed
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pubmed-article:10597469pubmed:authorpubmed-author:WilliamsJ TJTlld:pubmed
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pubmed-article:10597469pubmed:volume17 Suppl 1lld:pubmed
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pubmed-article:10597469pubmed:dateRevised2010-11-18lld:pubmed
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pubmed-article:10597469pubmed:articleTitleAsymptotic power of likelihood-ratio tests for detecting quantitative trait loci using the COGA data.lld:pubmed
pubmed-article:10597469pubmed:affiliationDepartment of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245-0549, USA.lld:pubmed
pubmed-article:10597469pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:10597469pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed