| pubmed-article:10588727 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10588727 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:10588727 | lifeskim:mentions | umls-concept:C0754728 | lld:lifeskim |
| pubmed-article:10588727 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:10588727 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:10588727 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:10588727 | pubmed:issue | 25 | lld:pubmed |
| pubmed-article:10588727 | pubmed:dateCreated | 2000-1-5 | lld:pubmed |
| pubmed-article:10588727 | pubmed:abstractText | The recognition of mycobacterial cell wall components causes macrophages to secrete tumor necrosis factor alpha (TNF-alpha) and other cytokines that are essential for the development of a protective inflammatory response. We show that toll-like receptors are required for the induction of TNF-alpha in macrophages by Mycobacterium tuberculosis. Expression of a dominant negative form of MyD88 (a signaling component required for toll-like receptor signaling) in a mouse macrophage cell line blocks TNF-alpha production induced by M. tuberculosis. We identify toll-like receptor-2 (TLR2) as the specific toll-like receptor required for this induction by showing that expression of an inhibitory TLR2 (TLR2-P681H) blocks TNF-alpha production induced by whole M. tuberculosis. Further, we show that TLR2-dependent signaling mediates responses to mycobacterial cell wall fractions enriched for lipoarrabinomannan, mycolylarabinogalactan-peptidoglycan complex, or M. tuberculosis total lipids. Thus, although many mycobacterial cell wall fractions are identified to be inflammatory, all require TLR2 for induction of TNF-alpha in macrophages. These data suggest that TLR2 is essential for the induction of a protective immune response to mycobacteria. | lld:pubmed |
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| pubmed-article:10588727 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10588727 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10588727 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10588727 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10588727 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:10588727 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:10588727 | pubmed:author | pubmed-author:SmithK DKD | lld:pubmed |
| pubmed-article:10588727 | pubmed:author | pubmed-author:UnderhillD... | lld:pubmed |
| pubmed-article:10588727 | pubmed:author | pubmed-author:AderemAA | lld:pubmed |
| pubmed-article:10588727 | pubmed:author | pubmed-author:OzinskyAA | lld:pubmed |
| pubmed-article:10588727 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10588727 | pubmed:day | 7 | lld:pubmed |
| pubmed-article:10588727 | pubmed:volume | 96 | lld:pubmed |
| pubmed-article:10588727 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10588727 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10588727 | pubmed:pagination | 14459-63 | lld:pubmed |
| pubmed-article:10588727 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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