| pubmed-article:10586083 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10586083 | lifeskim:mentions | umls-concept:C0032285 | lld:lifeskim |
| pubmed-article:10586083 | lifeskim:mentions | umls-concept:C0458827 | lld:lifeskim |
| pubmed-article:10586083 | lifeskim:mentions | umls-concept:C0040648 | lld:lifeskim |
| pubmed-article:10586083 | lifeskim:mentions | umls-concept:C0079904 | lld:lifeskim |
| pubmed-article:10586083 | lifeskim:mentions | umls-concept:C0700624 | lld:lifeskim |
| pubmed-article:10586083 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
| pubmed-article:10586083 | lifeskim:mentions | umls-concept:C1705630 | lld:lifeskim |
| pubmed-article:10586083 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:10586083 | pubmed:dateCreated | 2000-1-6 | lld:pubmed |
| pubmed-article:10586083 | pubmed:abstractText | The NF-kappa B/Rel family of transcription factors induces many genes involved in immune and inflammatory responses. Mice with germline deletions of individual NF-kappa B/Rel subunits have different phenotypes, suggesting that the NF-kappa B/Rel transcription factors have different functions. We tested whether c-Rel promotes allergic asthma using a murine model of allergen-induced pulmonary inflammation and airway hyperresponsiveness. Our investigation focused on c-Rel, which is expressed in lymphoid cells and is important for lymphocyte activation. In response to allergen sensitization and challenge, c-Rel-deficient mice did not develop increases in pulmonary inflammation, bronchoalveolar lavage fluid eosinophilia, or total serum IgE. c-Rel deficiency also prevented the induction of airway hyperresponsiveness. Allergen-treated wild-type mice had increased DNA binding to an NF-kappa B consensus site. Chemokine expression was altered in allergen-treated c-Rel-deficient mice. Monocyte chemoattractant protein-1, which is regulated by NF-kappa B, was decreased in allergen-treated c-Rel-deficient mice relative to wild-type controls. The increase in NF-kappa B/Rel transcription factors after allergen challenge in wild-type mice and the decrease in allergen reactivity found in c-Rel-deficient mice indicate that c-Rel promotes allergic inflammation. Alteration of pulmonary chemokine expression in c-Rel-deficient mice may inhibit allergen-induced pulmonary inflammation and airway hyperresponsiveness. | lld:pubmed |
| pubmed-article:10586083 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10586083 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10586083 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10586083 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10586083 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10586083 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:10586083 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10586083 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:10586083 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:10586083 | pubmed:author | pubmed-author:WangYY | lld:pubmed |
| pubmed-article:10586083 | pubmed:author | pubmed-author:KobzikLL | lld:pubmed |
| pubmed-article:10586083 | pubmed:author | pubmed-author:PerkinsD LDL | lld:pubmed |
| pubmed-article:10586083 | pubmed:author | pubmed-author:MarkD ADA | lld:pubmed |
| pubmed-article:10586083 | pubmed:author | pubmed-author:LashP RPR | lld:pubmed |
| pubmed-article:10586083 | pubmed:author | pubmed-author:De SanctisG... | lld:pubmed |
| pubmed-article:10586083 | pubmed:author | pubmed-author:FinnP WPW | lld:pubmed |
| pubmed-article:10586083 | pubmed:author | pubmed-author:HeH ZHZ | lld:pubmed |
| pubmed-article:10586083 | pubmed:author | pubmed-author:DonovanC ECE | lld:pubmed |
| pubmed-article:10586083 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10586083 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:10586083 | pubmed:volume | 163 | lld:pubmed |
| pubmed-article:10586083 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10586083 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10586083 | pubmed:pagination | 6827-33 | lld:pubmed |
| pubmed-article:10586083 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:10586083 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10586083 | pubmed:articleTitle | NF-kappa B/Rel transcription factors: c-Rel promotes airway hyperresponsiveness and allergic pulmonary inflammation. | lld:pubmed |
| pubmed-article:10586083 | pubmed:affiliation | Pulmonary Division, Brigham and Women's Hospital, Boston, MA 02115, USA. | lld:pubmed |
| pubmed-article:10586083 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10586083 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10586083 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:19696 | entrezgene:pubmed | pubmed-article:10586083 | lld:entrezgene |
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