| pubmed-article:10585468 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10585468 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:10585468 | lifeskim:mentions | umls-concept:C0038323 | lld:lifeskim |
| pubmed-article:10585468 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:10585468 | lifeskim:mentions | umls-concept:C0032615 | lld:lifeskim |
| pubmed-article:10585468 | lifeskim:mentions | umls-concept:C0220905 | lld:lifeskim |
| pubmed-article:10585468 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:10585468 | pubmed:issue | 50 | lld:pubmed |
| pubmed-article:10585468 | pubmed:dateCreated | 2000-1-13 | lld:pubmed |
| pubmed-article:10585468 | pubmed:abstractText | Dietary polyunsaturated fatty acids (PUFA) are negative regulators of hepatic lipogenesis that exert their effects primarily at the level of transcription. Sterol regulatory element-binding proteins (SREBPs) are transcription factors responsible for the regulation of cholesterol, fatty acid, and triglyceride synthesis. In particular, SREBP-1 is known to play a crucial role in the regulation of lipogenic gene expression in the liver. To explore the possible involvement of SREBP-1 in the suppression of hepatic lipogenesis by PUFA, we challenged wild-type mice and transgenic mice overexpressing a mature form of SREBP-1 in the liver with dietary PUFA. In the liver of wild-type mice, dietary PUFA drastically decreased the mature, cleaved form of SREBP-1 protein in the nucleus, whereas the precursor, uncleaved form in the membranes was not suppressed. The decreases in mature SREBP-1 paralleled those in mRNAs for lipogenic enzymes such as fatty acid synthase and acetyl-CoA carboxylase. In the transgenic mice, dietary PUFA did not reduce the amount of transgenic SREBP-1 protein, excluding the possibility that PUFA accelerated the degradation of mature SREBP-1. The resulting sustained expression of mature SREBP-1 almost completely canceled the suppression of lipogenic gene expression by PUFA in the SREBP-1 transgenic mice. These results demonstrate that the suppressive effect of PUFA on lipogenic enzyme genes in the liver is caused by a decrease in the mature form of SREBP-1 protein, which is presumably due to the reduced cleavage of SREBP-1 precursor protein. | lld:pubmed |
| pubmed-article:10585468 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:10585468 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10585468 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10585468 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:10585468 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:10585468 | pubmed:author | pubmed-author:TamuraYY | lld:pubmed |
| pubmed-article:10585468 | pubmed:author | pubmed-author:OhashiKK | lld:pubmed |
| pubmed-article:10585468 | pubmed:author | pubmed-author:HaradaKK | lld:pubmed |
| pubmed-article:10585468 | pubmed:author | pubmed-author:NagaiRR | lld:pubmed |
| pubmed-article:10585468 | pubmed:author | pubmed-author:IshibashiSS | lld:pubmed |
| pubmed-article:10585468 | pubmed:author | pubmed-author:YamadaNN | lld:pubmed |
| pubmed-article:10585468 | pubmed:author | pubmed-author:OkazakiHH | lld:pubmed |
| pubmed-article:10585468 | pubmed:author | pubmed-author:IizukaYY | lld:pubmed |
| pubmed-article:10585468 | pubmed:author | pubmed-author:GotodaTT | lld:pubmed |
| pubmed-article:10585468 | pubmed:author | pubmed-author:YahagiNN | lld:pubmed |
| pubmed-article:10585468 | pubmed:author | pubmed-author:ShimanoHH | lld:pubmed |
| pubmed-article:10585468 | pubmed:author | pubmed-author:OsugaJJ | lld:pubmed |
| pubmed-article:10585468 | pubmed:author | pubmed-author:HastyA HAH | lld:pubmed |
| pubmed-article:10585468 | pubmed:author | pubmed-author:ShionoiriFF | lld:pubmed |
| pubmed-article:10585468 | pubmed:author | pubmed-author:Amemiya-KudoM... | lld:pubmed |
| pubmed-article:10585468 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10585468 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:10585468 | pubmed:volume | 274 | lld:pubmed |
| pubmed-article:10585468 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10585468 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10585468 | pubmed:pagination | 35840-4 | lld:pubmed |
| pubmed-article:10585468 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:10585468 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10585468 | pubmed:articleTitle | A crucial role of sterol regulatory element-binding protein-1 in the regulation of lipogenic gene expression by polyunsaturated fatty acids. | lld:pubmed |
| pubmed-article:10585468 | pubmed:affiliation | Department of Metabolic Diseases, Faculty of Medicine, University of Tokyo, Tokyo 113-8655, Japan. | lld:pubmed |
| pubmed-article:10585468 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10585468 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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