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pubmed-article:10585342pubmed:abstractTextSerum human chorionic gonadotropin (hCG) and hCG free beta-subunit tests are used in combination with unconjugated estriol and alpha-fetoprotein in the triple screen test, and with the addition of inhibin-A in the quadruple marker test for detecting Down syndrome in the second trimester of pregnancy. These tests have a limited detection rate for Down syndrome: approximately 40% for hCG or free beta-subunit alone, approximately 60% for the triple screen test, and approximately 70% for the quadruple marker test, all at 5%, or a relatively high, false-positive rate. New tests are needed with higher detection and lower false rates. Hyperglycosylated hCG (also known as invasive trophoblast antigen or ITA) is a new test. It specifically detects a unique oligosaccharide variant of hCG associated with Down syndrome pregnancies. We evaluated this new Down syndrome-directed test in prenatal diagnosis.lld:pubmed
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pubmed-article:10585342pubmed:articleTitleHyperglycosylated human chorionic gonadotropin (invasive trophoblast antigen) immunoassay: A new basis for gestational Down syndrome screening.lld:pubmed
pubmed-article:10585342pubmed:affiliationDepartment of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06510, USA. larry@hCGlab.comlld:pubmed
pubmed-article:10585342pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:10585342pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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