| pubmed-article:10580406 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10580406 | lifeskim:mentions | umls-concept:C0019682 | lld:lifeskim |
| pubmed-article:10580406 | lifeskim:mentions | umls-concept:C0019699 | lld:lifeskim |
| pubmed-article:10580406 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:10580406 | lifeskim:mentions | umls-concept:C0596138 | lld:lifeskim |
| pubmed-article:10580406 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:10580406 | lifeskim:mentions | umls-concept:C0598312 | lld:lifeskim |
| pubmed-article:10580406 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:10580406 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:10580406 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:10580406 | pubmed:issue | 17 | lld:pubmed |
| pubmed-article:10580406 | pubmed:dateCreated | 1999-12-17 | lld:pubmed |
| pubmed-article:10580406 | pubmed:abstractText | The ability of CD8+ T lymphocytes to suppress the transcription and replication of HIV-1 is well documented. We have demonstrated that the factor(s) responsible for the suppression of HIV-1 LTR-mediated gene expression are not the CC chemokines RANTES, MIP-1alpha, and MIP-1beta. Interestingly, these and other chemokines and cytokines are produced by both CD8+ and CD4+ T lymphocytes. On the presumption that CD4+ T lymphocytes may also be able to modulate HIV-1 expression in vitro we assessed the LTR-modulatory effects of a panel of culture supernatants derived from stimulated CD4+ T lymphocytes from HIV-positive patients and uninfected controls. Supernatants of both CD4+ and CD8+ T cells mediated a suppression of LTR-driven gene expression in Jurkat T cells and an enhancement of gene expression in U38 monocytic cells. On the basis of these results, and using a herpesvirus saimiri (HVS)-transformed CD4+ T lymphocyte clone (HVSCD4), we demonstrate that both suppressive and enhancing effects are dose dependent. Furthermore, we have shown that supernatants of both HVSCD4 and HVSCD8 cells suppress LTR-mediated gene expression and HIV-1 replication in transfected/infected T cells. In U1 monocytic cells, supernatants of both CD4+ and CD8+ lymphocytes from an HIV-1-infected individual enhanced LTR-mediated gene expression, HIV-1 replication, and TNF-alpha production. However, only these effects as induced by CD8+ T cells were sensitive to the G protein inhibitor pertussis toxin. These results indicate that factors produced by both CD4+ and CD8+ T cells exert dichotomous effects on HIV-1 gene expression and replication in T cells and monocytes. | lld:pubmed |
| pubmed-article:10580406 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10580406 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10580406 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10580406 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10580406 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10580406 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10580406 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10580406 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:10580406 | pubmed:issn | 0889-2229 | lld:pubmed |
| pubmed-article:10580406 | pubmed:author | pubmed-author:RichardsC DCD | lld:pubmed |
| pubmed-article:10580406 | pubmed:author | pubmed-author:RosenthalK... | lld:pubmed |
| pubmed-article:10580406 | pubmed:author | pubmed-author:McKeeP RPR | lld:pubmed |
| pubmed-article:10580406 | pubmed:author | pubmed-author:LeiteJ JJJ | lld:pubmed |
| pubmed-article:10580406 | pubmed:author | pubmed-author:CopelandK FKF | lld:pubmed |
| pubmed-article:10580406 | pubmed:author | pubmed-author:BienzleDD | lld:pubmed |
| pubmed-article:10580406 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10580406 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:10580406 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:10580406 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10580406 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10580406 | pubmed:pagination | 1553-61 | lld:pubmed |
| pubmed-article:10580406 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:10580406 | pubmed:meshHeading | pubmed-meshheading:10580406... | lld:pubmed |
| pubmed-article:10580406 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10580406 | pubmed:articleTitle | T cell-derived suppressive activity: evidence of autocrine noncytolytic control of HIV type 1 transcription and replication. | lld:pubmed |
| pubmed-article:10580406 | pubmed:affiliation | Department of Pathology and Molecular Medicine, McMaster University Health Sciences Centre, Hamilton, Ontario, Canada. | lld:pubmed |
| pubmed-article:10580406 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10580406 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:10580406 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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