Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:10575011rdf:typepubmed:Citationlld:pubmed
pubmed-article:10575011lifeskim:mentionsumls-concept:C0162508lld:lifeskim
pubmed-article:10575011lifeskim:mentionsumls-concept:C1708800lld:lifeskim
pubmed-article:10575011lifeskim:mentionsumls-concept:C0037083lld:lifeskim
pubmed-article:10575011lifeskim:mentionsumls-concept:C0031727lld:lifeskim
pubmed-article:10575011lifeskim:mentionsumls-concept:C0033640lld:lifeskim
pubmed-article:10575011lifeskim:mentionsumls-concept:C1367675lld:lifeskim
pubmed-article:10575011lifeskim:mentionsumls-concept:C1332359lld:lifeskim
pubmed-article:10575011lifeskim:mentionsumls-concept:C1514562lld:lifeskim
pubmed-article:10575011lifeskim:mentionsumls-concept:C1883221lld:lifeskim
pubmed-article:10575011lifeskim:mentionsumls-concept:C1710082lld:lifeskim
pubmed-article:10575011lifeskim:mentionsumls-concept:C0439855lld:lifeskim
pubmed-article:10575011lifeskim:mentionsumls-concept:C0376315lld:lifeskim
pubmed-article:10575011lifeskim:mentionsumls-concept:C1150582lld:lifeskim
pubmed-article:10575011lifeskim:mentionsumls-concept:C1515877lld:lifeskim
pubmed-article:10575011lifeskim:mentionsumls-concept:C1883204lld:lifeskim
pubmed-article:10575011lifeskim:mentionsumls-concept:C1879547lld:lifeskim
pubmed-article:10575011lifeskim:mentionsumls-concept:C0205088lld:lifeskim
pubmed-article:10575011lifeskim:mentionsumls-concept:C1880389lld:lifeskim
pubmed-article:10575011pubmed:issue49lld:pubmed
pubmed-article:10575011pubmed:dateCreated2000-2-3lld:pubmed
pubmed-article:10575011pubmed:abstractTextAxin negatively regulates the Wnt pathway during axis formation and plays a central role in cell growth control and tumorigenesis. We found that Axin also serves as a scaffold protein for mitogen-activated protein kinase activation and further determined the structural requirement for this activation. Overexpression of Axin in 293T cells leads to differential activation of mitogen-activated protein kinases, with robust induction for c-Jun NH(2)-terminal kinase (JNK)/stress-activated protein kinase, moderate induction for p38, and negligible induction for extracellular signal-regulated kinase. Axin forms a complex with MEKK1 through a novel domain that we term MEKK1-interacting domain. MKK4 and MKK7, which act downstream of MEKK1, are also involved in Axin-mediated JNK activation. Domains essential in Wnt signaling, i. e. binding sites for adenomatous polyposis coli, glycogen synthase kinase-3beta, and beta-catenin, are not required for JNK activation, suggesting distinct domain utilization between the Wnt pathway and JNK signal transduction. Dimerization/oligomerization of Axin through its C terminus is required for JNK activation, although MEKK1 is capable of binding C terminus-deleted monomeric Axin. Furthermore, Axin without the MEKK1-interacting domain has a dominant-negative effect on JNK activation by wild-type Axin. Our results suggest that Axin, in addition to its function in the Wnt pathway, may play a dual role in cells through its activation of JNK/stress-activated protein kinase signaling cascade.lld:pubmed
pubmed-article:10575011pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10575011pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10575011pubmed:languageenglld:pubmed
pubmed-article:10575011pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10575011pubmed:citationSubsetIMlld:pubmed
pubmed-article:10575011pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10575011pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10575011pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10575011pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10575011pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10575011pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10575011pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10575011pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10575011pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10575011pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10575011pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10575011pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10575011pubmed:statusMEDLINElld:pubmed
pubmed-article:10575011pubmed:monthDeclld:pubmed
pubmed-article:10575011pubmed:issn0021-9258lld:pubmed
pubmed-article:10575011pubmed:authorpubmed-author:HanJJlld:pubmed
pubmed-article:10575011pubmed:authorpubmed-author:WuJJlld:pubmed
pubmed-article:10575011pubmed:authorpubmed-author:KARP KPKlld:pubmed
pubmed-article:10575011pubmed:authorpubmed-author:ZhangYYlld:pubmed
pubmed-article:10575011pubmed:authorpubmed-author:WangXXlld:pubmed
pubmed-article:10575011pubmed:issnTypePrintlld:pubmed
pubmed-article:10575011pubmed:day3lld:pubmed
pubmed-article:10575011pubmed:volume274lld:pubmed
pubmed-article:10575011pubmed:ownerNLMlld:pubmed
pubmed-article:10575011pubmed:authorsCompleteYlld:pubmed
pubmed-article:10575011pubmed:pagination35247-54lld:pubmed
pubmed-article:10575011pubmed:dateRevised2011-11-17lld:pubmed
pubmed-article:10575011pubmed:meshHeadingpubmed-meshheading:10575011...lld:pubmed
pubmed-article:10575011pubmed:meshHeadingpubmed-meshheading:10575011...lld:pubmed
pubmed-article:10575011pubmed:meshHeadingpubmed-meshheading:10575011...lld:pubmed
pubmed-article:10575011pubmed:meshHeadingpubmed-meshheading:10575011...lld:pubmed
pubmed-article:10575011pubmed:meshHeadingpubmed-meshheading:10575011...lld:pubmed
pubmed-article:10575011pubmed:meshHeadingpubmed-meshheading:10575011...lld:pubmed
pubmed-article:10575011pubmed:meshHeadingpubmed-meshheading:10575011...lld:pubmed
pubmed-article:10575011pubmed:meshHeadingpubmed-meshheading:10575011...lld:pubmed
pubmed-article:10575011pubmed:meshHeadingpubmed-meshheading:10575011...lld:pubmed
pubmed-article:10575011pubmed:meshHeadingpubmed-meshheading:10575011...lld:pubmed
pubmed-article:10575011pubmed:meshHeadingpubmed-meshheading:10575011...lld:pubmed
pubmed-article:10575011pubmed:meshHeadingpubmed-meshheading:10575011...lld:pubmed
pubmed-article:10575011pubmed:meshHeadingpubmed-meshheading:10575011...lld:pubmed
pubmed-article:10575011pubmed:meshHeadingpubmed-meshheading:10575011...lld:pubmed
pubmed-article:10575011pubmed:meshHeadingpubmed-meshheading:10575011...lld:pubmed
pubmed-article:10575011pubmed:meshHeadingpubmed-meshheading:10575011...lld:pubmed
pubmed-article:10575011pubmed:meshHeadingpubmed-meshheading:10575011...lld:pubmed
pubmed-article:10575011pubmed:meshHeadingpubmed-meshheading:10575011...lld:pubmed
pubmed-article:10575011pubmed:meshHeadingpubmed-meshheading:10575011...lld:pubmed
pubmed-article:10575011pubmed:meshHeadingpubmed-meshheading:10575011...lld:pubmed
pubmed-article:10575011pubmed:year1999lld:pubmed
pubmed-article:10575011pubmed:articleTitleAxin forms a complex with MEKK1 and activates c-Jun NH(2)-terminal kinase/stress-activated protein kinase through domains distinct from Wnt signaling.lld:pubmed
pubmed-article:10575011pubmed:affiliationRegulatory Biology Laboratory, Institute of Molecular and Cell Biology, National University of Singapore, 30 Medical Drive, Singapore 117609, Republic of Singapore.lld:pubmed
pubmed-article:10575011pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:10575011pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
pubmed-article:10575011pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
entrez-gene:12005entrezgene:pubmedpubmed-article:10575011lld:entrezgene
entrez-gene:26401entrezgene:pubmedpubmed-article:10575011lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:10575011lld:entrezgene
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10575011lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10575011lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10575011lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10575011lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10575011lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10575011lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10575011lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10575011lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10575011lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10575011lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10575011lld:pubmed