| pubmed-article:10570309 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10570309 | lifeskim:mentions | umls-concept:C0014070 | lld:lifeskim |
| pubmed-article:10570309 | lifeskim:mentions | umls-concept:C0011303 | lld:lifeskim |
| pubmed-article:10570309 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:10570309 | lifeskim:mentions | umls-concept:C1098262 | lld:lifeskim |
| pubmed-article:10570309 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:10570309 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:10570309 | pubmed:dateCreated | 1999-12-20 | lld:pubmed |
| pubmed-article:10570309 | pubmed:abstractText | We examined the role of B7-1 and B7-2, costimulatory molecules critical to full activation of T cells, in the development of Theiler's murine encephalomyelitis virus-induced demyelinating disease (TMEV-IDD). Treatment with mAbs to B7-1 resulted in significant suppression of the development of this disease both clinically and histologically. In mice treated with these mAbs, the production of TNF-alpha and IFN-gamma in the spleen cells was decreased. The delayed-type hypersensitivity and T cell proliferative response specific for TMEV were decreased by this treatment. In contrast, treatment with Abs to B7-2, resulted in no effect on TMEV-IDD. These data suggest that B7-1 is critically involved in the pathogenesis of TMEV-IDD and that Abs to B7-1 could be a novel therapeutic approach in the clinical treatment of demyelinating diseases such as human multiple sclerosis. | lld:pubmed |
| pubmed-article:10570309 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10570309 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10570309 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:10570309 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10570309 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10570309 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10570309 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10570309 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10570309 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10570309 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10570309 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10570309 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:10570309 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:10570309 | pubmed:author | pubmed-author:InoueAA | lld:pubmed |
| pubmed-article:10570309 | pubmed:author | pubmed-author:YamazakiMM | lld:pubmed |
| pubmed-article:10570309 | pubmed:author | pubmed-author:KohC SCS | lld:pubmed |
| pubmed-article:10570309 | pubmed:author | pubmed-author:YagitaHH | lld:pubmed |
| pubmed-article:10570309 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10570309 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:10570309 | pubmed:volume | 163 | lld:pubmed |
| pubmed-article:10570309 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10570309 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10570309 | pubmed:pagination | 6180-6 | lld:pubmed |
| pubmed-article:10570309 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:10570309 | pubmed:meshHeading | pubmed-meshheading:10570309... | lld:pubmed |
| pubmed-article:10570309 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10570309 | pubmed:articleTitle | Effect of anti-B7-1 and anti-B7-2 mAb on Theiler's murine encephalomyelitis virus-induced demyelinating disease. | lld:pubmed |
| pubmed-article:10570309 | pubmed:affiliation | Third Department of Medicine (Neurology), Shinshu University School of Medicine, Matsumoto, Japan; and Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan. | lld:pubmed |
| pubmed-article:10570309 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10570309 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10570309 | lld:pubmed |
