| pubmed-article:10567499 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10567499 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:10567499 | lifeskim:mentions | umls-concept:C0026769 | lld:lifeskim |
| pubmed-article:10567499 | lifeskim:mentions | umls-concept:C0012634 | lld:lifeskim |
| pubmed-article:10567499 | lifeskim:mentions | umls-concept:C0534519 | lld:lifeskim |
| pubmed-article:10567499 | lifeskim:mentions | umls-concept:C0035696 | lld:lifeskim |
| pubmed-article:10567499 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:10567499 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:10567499 | lifeskim:mentions | umls-concept:C0205100 | lld:lifeskim |
| pubmed-article:10567499 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:10567499 | lifeskim:mentions | umls-concept:C0439611 | lld:lifeskim |
| pubmed-article:10567499 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:10567499 | pubmed:dateCreated | 1999-12-29 | lld:pubmed |
| pubmed-article:10567499 | pubmed:abstractText | The cysteine protease caspase-1 plays a crucial part in the inflammatory process due to its ability to proteolitically activate proinflammatory cytokine precursors, such as interleukin (IL)-1beta and IL-18. Multiple sclerosis is a chronic inflammatory demyelinating disease of the CNS in which the pathogenic process is mainly orchestrated by proinflammatory cytokines. The role of caspase-1 in multiple sclerosis was evaluated by measuring its mRNA levels in peripheral blood mononuclear cells (PBMCs) from seven patients with relapsing-remitting multiple sclerosis every 15 days over a 1 year period. The recorded levels were compared with clinical and MRI evidence of disease activity. Brain MRI was performed monthly in each patient. Caspase-1 mRNA levels were significantly increased in PBMCs from patients with multiple sclerosis compared with healthy controls (p<0.001). In patients with multiple sclerosis, a twofold to threefold increase of caspase-1 mRNA mean level was found in the week preceding an acute attack (p<0. 05). The magnitude of caspase-1 mRNA increase correlated with the number of new (p=0.01) but not persisting gadolinium enhancing brain MRI lesions. In conclusion, caspase-1 might be involved in the immune mediated process underlying CNS inflammation and might represent a suitable peripheral immunological marker of disease activity in multiple sclerosis. | lld:pubmed |
| pubmed-article:10567499 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10567499 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10567499 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10567499 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10567499 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10567499 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10567499 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10567499 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10567499 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10567499 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10567499 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10567499 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:10567499 | pubmed:issn | 0022-3050 | lld:pubmed |
| pubmed-article:10567499 | pubmed:author | pubmed-author:MartinoGG | lld:pubmed |
| pubmed-article:10567499 | pubmed:author | pubmed-author:ComiGG | lld:pubmed |
| pubmed-article:10567499 | pubmed:author | pubmed-author:MartinelliVV | lld:pubmed |
| pubmed-article:10567499 | pubmed:author | pubmed-author:FilippiMM | lld:pubmed |
| pubmed-article:10567499 | pubmed:author | pubmed-author:FurlanRR | lld:pubmed |
| pubmed-article:10567499 | pubmed:author | pubmed-author:GrimaldiL MLM | lld:pubmed |
| pubmed-article:10567499 | pubmed:author | pubmed-author:BergamiAA | lld:pubmed |
| pubmed-article:10567499 | pubmed:author | pubmed-author:PolianiP LPL | lld:pubmed |
| pubmed-article:10567499 | pubmed:author | pubmed-author:RoccaM AMA | lld:pubmed |
| pubmed-article:10567499 | pubmed:author | pubmed-author:DesinaGG | lld:pubmed |
| pubmed-article:10567499 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10567499 | pubmed:volume | 67 | lld:pubmed |
| pubmed-article:10567499 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10567499 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10567499 | pubmed:pagination | 785-8 | lld:pubmed |
| pubmed-article:10567499 | pubmed:dateRevised | 2008-11-20 | lld:pubmed |
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| pubmed-article:10567499 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10567499 | pubmed:articleTitle | Peripheral levels of caspase-1 mRNA correlate with disease activity in patients with multiple sclerosis; a preliminary study. | lld:pubmed |
| pubmed-article:10567499 | pubmed:affiliation | Experimental Neuroimmunotherapy Unit, Department of Neuroscience, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy. | lld:pubmed |
| pubmed-article:10567499 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10567499 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10567499 | lld:pubmed |
