| pubmed-article:10564811 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10564811 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:10564811 | lifeskim:mentions | umls-concept:C0014241 | lld:lifeskim |
| pubmed-article:10564811 | lifeskim:mentions | umls-concept:C0597298 | lld:lifeskim |
| pubmed-article:10564811 | lifeskim:mentions | umls-concept:C1956003 | lld:lifeskim |
| pubmed-article:10564811 | lifeskim:mentions | umls-concept:C0002345 | lld:lifeskim |
| pubmed-article:10564811 | lifeskim:mentions | umls-concept:C0072388 | lld:lifeskim |
| pubmed-article:10564811 | lifeskim:mentions | umls-concept:C1418833 | lld:lifeskim |
| pubmed-article:10564811 | lifeskim:mentions | umls-concept:C1999216 | lld:lifeskim |
| pubmed-article:10564811 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:10564811 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:10564811 | lifeskim:mentions | umls-concept:C2700640 | lld:lifeskim |
| pubmed-article:10564811 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:10564811 | pubmed:dateCreated | 2000-1-11 | lld:pubmed |
| pubmed-article:10564811 | pubmed:abstractText | ARD-1 is an endoribonuclease identified initially as the product of a human cDNA that complements mutations in rne, a gene that encodes Escherichia coli ribonuclease E. NIPP-1 was identified in bovine nuclear extracts as an inhibitor of protein phosphatase-1. Earlier work has shown that the protein-coding sequence of ARD-1 is identical to the carboxy-terminal third of NIPP-1. However, whether ARD-1 is present in eukaryotes as a distinct entity has been unclear, as neither ARD-1-specific transcripts nor ARD-1 protein were detected in mammalian cells in earlier studies. Here we show that ARD-1 exists in human cells as a discrete protein, and that the ARD-1 and NIPP-1 peptides are isoforms encoded by a single gene and the same alternatively spliced precursor RNA. A retained intron containing multiple translation stop codons that are configured to terminate translation and initiate nonsense-mediated decay, limits the production of cellular ARD-1 protein. Our results establish the process by which functionally disparate ARD-1 and NIPP-1 peptides are generated from the protein-coding sequence of the same gene in human cells. | lld:pubmed |
| pubmed-article:10564811 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10564811 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10564811 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10564811 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10564811 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10564811 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10564811 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10564811 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10564811 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10564811 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10564811 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10564811 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10564811 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10564811 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10564811 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10564811 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:10564811 | pubmed:issn | 0378-1119 | lld:pubmed |
| pubmed-article:10564811 | pubmed:author | pubmed-author:CohenPP | lld:pubmed |
| pubmed-article:10564811 | pubmed:author | pubmed-author:CohenS NSN | lld:pubmed |
| pubmed-article:10564811 | pubmed:author | pubmed-author:ChangA CAC | lld:pubmed |
| pubmed-article:10564811 | pubmed:author | pubmed-author:Claverie-Mart... | lld:pubmed |
| pubmed-article:10564811 | pubmed:author | pubmed-author:Trinkle-Mulca... | lld:pubmed |
| pubmed-article:10564811 | pubmed:author | pubmed-author:SohlbergBB | lld:pubmed |
| pubmed-article:10564811 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10564811 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:10564811 | pubmed:volume | 240 | lld:pubmed |
| pubmed-article:10564811 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10564811 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10564811 | pubmed:pagination | 45-55 | lld:pubmed |
| pubmed-article:10564811 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:10564811 | pubmed:meshHeading | pubmed-meshheading:10564811... | lld:pubmed |
| pubmed-article:10564811 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10564811 | pubmed:articleTitle | Alternative splicing regulates the production of ARD-1 endoribonuclease and NIPP-1, an inhibitor of protein phosphatase-1, as isoforms encoded by the same gene. | lld:pubmed |
| pubmed-article:10564811 | pubmed:affiliation | MRC Protein Phosphorylation Unit, Department of Biochemistry, University of Dundee, Dundee, UK. | lld:pubmed |
| pubmed-article:10564811 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10564811 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10564811 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:5511 | entrezgene:pubmed | pubmed-article:10564811 | lld:entrezgene |
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