| pubmed-article:10564188 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10564188 | lifeskim:mentions | umls-concept:C1135183 | lld:lifeskim |
| pubmed-article:10564188 | lifeskim:mentions | umls-concept:C1135918 | lld:lifeskim |
| pubmed-article:10564188 | lifeskim:mentions | umls-concept:C0040578 | lld:lifeskim |
| pubmed-article:10564188 | lifeskim:mentions | umls-concept:C0442043 | lld:lifeskim |
| pubmed-article:10564188 | lifeskim:mentions | umls-concept:C1428114 | lld:lifeskim |
| pubmed-article:10564188 | lifeskim:mentions | umls-concept:C2713359 | lld:lifeskim |
| pubmed-article:10564188 | lifeskim:mentions | umls-concept:C1879746 | lld:lifeskim |
| pubmed-article:10564188 | lifeskim:mentions | umls-concept:C1547011 | lld:lifeskim |
| pubmed-article:10564188 | pubmed:issue | 5 Pt 1 | lld:pubmed |
| pubmed-article:10564188 | pubmed:dateCreated | 1999-12-14 | lld:pubmed |
| pubmed-article:10564188 | pubmed:abstractText | Spontaneous, localized intracellular Ca(2+) concentration ([Ca(2+)](i)) transients (Ca(2+) sparks) in skeletal, cardiac, and smooth muscle cells are thought to represent Ca(2+) release through ryanodine-receptor (RyR) channels. In porcine tracheal smooth muscle (TSM) cells, ACh induces propagating [Ca(2+)](i) oscillations that also represent Ca(2+) release through RyR channels. We used real-time confocal imaging to examine the spatial and temporal relationships of Ca(2+) sparks to propagating [Ca(2+)](i) oscillations in TSM cells. Ca(2+) sparks within an intracellular region displayed different spatial Ca(2+) distributions with every occurrence. The amplitudes of Ca(2+) sparks within a region were approximately integer multiples of the smallest response. However, across different regions, the attributes of Ca(2+) sparks varied considerably. Individual sparks were often grouped together and coupled across adjacent regions. Fusion of individual sparks produced large local elevations in [Ca(2+)](i) that occasionally triggered a propagating [Ca(2+)](i) wave. The incidence of sparks was increased by ryanodine and caffeine but was unaffected by removal of extracellular Ca(2+). Exposure to ACh triggered repetitive, propagating [Ca(2+)](i) oscillations that always originated from foci with a high spark incidence. The [Ca(2+)](i) oscillations disappeared with the removal of ACh, and Ca(2+) sparks reappeared. We conclude that agonist-induced [Ca(2+)](i) oscillations represent a spatial and temporal integration of local Ca(2+)-release events through RyR channels in TSM cells. | lld:pubmed |
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| pubmed-article:10564188 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10564188 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10564188 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10564188 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10564188 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10564188 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10564188 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10564188 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10564188 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:10564188 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:10564188 | pubmed:author | pubmed-author:SieckG CGC | lld:pubmed |
| pubmed-article:10564188 | pubmed:author | pubmed-author:KannanM SMS | lld:pubmed |
| pubmed-article:10564188 | pubmed:author | pubmed-author:PrakashY SYS | lld:pubmed |
| pubmed-article:10564188 | pubmed:author | pubmed-author:PabelickC MCM | lld:pubmed |
| pubmed-article:10564188 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10564188 | pubmed:volume | 277 | lld:pubmed |
| pubmed-article:10564188 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10564188 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10564188 | pubmed:pagination | L1018-25 | lld:pubmed |
| pubmed-article:10564188 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:10564188 | pubmed:meshHeading | pubmed-meshheading:10564188... | lld:pubmed |
| pubmed-article:10564188 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10564188 | pubmed:articleTitle | Spatial and temporal aspects of calcium sparks in porcine tracheal smooth muscle cells. | lld:pubmed |
| pubmed-article:10564188 | pubmed:affiliation | Department of Anesthesiology, Mayo Foundation, Rochester 55905, Minnesota, USA. | lld:pubmed |
| pubmed-article:10564188 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10564188 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10564188 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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