| pubmed-article:10558943 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10558943 | lifeskim:mentions | umls-concept:C0026691 | lld:lifeskim |
| pubmed-article:10558943 | lifeskim:mentions | umls-concept:C1457869 | lld:lifeskim |
| pubmed-article:10558943 | lifeskim:mentions | umls-concept:C0439662 | lld:lifeskim |
| pubmed-article:10558943 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:10558943 | pubmed:dateCreated | 2000-1-10 | lld:pubmed |
| pubmed-article:10558943 | pubmed:abstractText | Kawasaki disease (KD), an acute febrile disease in children of unknown etiology, is characterized by a vasculitis that may result in coronary artery aneurysms (CAAs). In new patients with KD, a selective and prolonged T cell unresponsiveness to activation via the T cell antigen receptor CD3 was observed, whereas proliferation to other stimuli was intact. This "split T cell anergy" delineated KD from other pediatric infections and autoimmune diseases and correlated with CAA formation (P<.001). A transient immune dysfunction was also suggested by an incomplete responsiveness to measles-mumps-rubella (MMR) vaccination in patients with KD versus controls (P<.0001; odds ratio, 15.6; 95% confidence interval, 4.8-51.1), which was overcome by revaccination(s). The reduced responsiveness to MMR in patients with KD suggests a subtle and predetermining immune dysfunction. An inherent immaturity to clear certain antigens may be an important cause that precipitates KD and the immune dysregulation during acute disease. | lld:pubmed |
| pubmed-article:10558943 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10558943 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10558943 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:10558943 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10558943 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10558943 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10558943 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10558943 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10558943 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10558943 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10558943 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10558943 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10558943 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10558943 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:10558943 | pubmed:issn | 0022-1899 | lld:pubmed |
| pubmed-article:10558943 | pubmed:author | pubmed-author:RoseM BMB | lld:pubmed |
| pubmed-article:10558943 | pubmed:author | pubmed-author:Wertheim-van... | lld:pubmed |
| pubmed-article:10558943 | pubmed:author | pubmed-author:KuijpersT WTW | lld:pubmed |
| pubmed-article:10558943 | pubmed:author | pubmed-author:van LierR ARA | lld:pubmed |
| pubmed-article:10558943 | pubmed:author | pubmed-author:OttenkampJJ | lld:pubmed |
| pubmed-article:10558943 | pubmed:author | pubmed-author:PinedaEE | lld:pubmed |
| pubmed-article:10558943 | pubmed:author | pubmed-author:WiegmanAA | lld:pubmed |
| pubmed-article:10558943 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10558943 | pubmed:volume | 180 | lld:pubmed |
| pubmed-article:10558943 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10558943 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10558943 | pubmed:pagination | 1869-77 | lld:pubmed |
| pubmed-article:10558943 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:10558943 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10558943 | pubmed:articleTitle | Kawasaki disease: a maturational defect in immune responsiveness. | lld:pubmed |
| pubmed-article:10558943 | pubmed:affiliation | Emma Children's Hospital, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands. T.W.Kuijpers@amc.uva.nl | lld:pubmed |
| pubmed-article:10558943 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10558943 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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