Linked Life Data

10558914

Source:http://linkedlifedata.com/resource/pubmed/id/10558914

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:10558914rdf:typepubmed:Citationlld:pubmed
pubmed-article:10558914lifeskim:mentionsumls-concept:C0035820lld:lifeskim
pubmed-article:10558914lifeskim:mentionsumls-concept:C0058980lld:lifeskim
pubmed-article:10558914lifeskim:mentionsumls-concept:C0596577lld:lifeskim
pubmed-article:10558914lifeskim:mentionsumls-concept:C1514566lld:lifeskim
pubmed-article:10558914pubmed:issue2lld:pubmed
pubmed-article:10558914pubmed:dateCreated1999-12-20lld:pubmed
pubmed-article:10558914pubmed:abstractTextFlavonoids such as genistein and quercetin suppress tumor cell growth in vitro and in vivo. Many metabolic enzymes, including protein kinases, are known to be inhibited by flavonoids, yet the molecular targets and biochemical mechanisms of the tumor growth suppression remain unclear. Here, we find that flavonoids inhibit protein synthesis in both mouse and human leukemia cells. This inhibition is associated with phosphorylation of the alpha-subunit of eukaryotic initiation factor 2 (eIF2alpha), a key regulatory mechanism of protein translation. Three mammalian eIF2alpha kinases have been identified: the interferon-inducible double-stranded RNA-dependent kinase (PKR), the heme-regulated inhibitor (HRI), and the very recently discovered PERK/PEK. We find that all of these eIF2alpha kinases can be activated by quercetin and genistein, indicating redundant roles of the eIF2alpha kinases. Thus, activation of eIF2alpha kinases appears to be a mechanism by which flavonoids can inhibit the growth of tumor and leukemia cells.lld:pubmed
pubmed-article:10558914pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10558914pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10558914pubmed:languageenglld:pubmed
pubmed-article:10558914pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10558914pubmed:citationSubsetIMlld:pubmed
pubmed-article:10558914pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10558914pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10558914pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10558914pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10558914pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10558914pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10558914pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10558914pubmed:statusMEDLINElld:pubmed
pubmed-article:10558914pubmed:monthNovlld:pubmed
pubmed-article:10558914pubmed:issn0006-291Xlld:pubmed
pubmed-article:10558914pubmed:authorpubmed-author:ItoTTlld:pubmed
pubmed-article:10558914pubmed:authorpubmed-author:MauW WWWlld:pubmed
pubmed-article:10558914pubmed:authorpubmed-author:WarnkenS PSPlld:pubmed
pubmed-article:10558914pubmed:copyrightInfoCopyright 1999 Academic Press.lld:pubmed
pubmed-article:10558914pubmed:issnTypePrintlld:pubmed
pubmed-article:10558914pubmed:day19lld:pubmed
pubmed-article:10558914pubmed:volume265lld:pubmed
pubmed-article:10558914pubmed:ownerNLMlld:pubmed
pubmed-article:10558914pubmed:authorsCompleteYlld:pubmed
pubmed-article:10558914pubmed:pagination589-94lld:pubmed
pubmed-article:10558914pubmed:dateRevised2009-11-19lld:pubmed
pubmed-article:10558914pubmed:meshHeadingpubmed-meshheading:10558914...lld:pubmed
pubmed-article:10558914pubmed:meshHeadingpubmed-meshheading:10558914...lld:pubmed
pubmed-article:10558914pubmed:meshHeadingpubmed-meshheading:10558914...lld:pubmed
pubmed-article:10558914pubmed:meshHeadingpubmed-meshheading:10558914...lld:pubmed
pubmed-article:10558914pubmed:meshHeadingpubmed-meshheading:10558914...lld:pubmed
pubmed-article:10558914pubmed:meshHeadingpubmed-meshheading:10558914...lld:pubmed
pubmed-article:10558914pubmed:meshHeadingpubmed-meshheading:10558914...lld:pubmed
pubmed-article:10558914pubmed:meshHeadingpubmed-meshheading:10558914...lld:pubmed
pubmed-article:10558914pubmed:meshHeadingpubmed-meshheading:10558914...lld:pubmed
pubmed-article:10558914pubmed:meshHeadingpubmed-meshheading:10558914...lld:pubmed
pubmed-article:10558914pubmed:meshHeadingpubmed-meshheading:10558914...lld:pubmed
pubmed-article:10558914pubmed:meshHeadingpubmed-meshheading:10558914...lld:pubmed
pubmed-article:10558914pubmed:meshHeadingpubmed-meshheading:10558914...lld:pubmed
pubmed-article:10558914pubmed:meshHeadingpubmed-meshheading:10558914...lld:pubmed
pubmed-article:10558914pubmed:meshHeadingpubmed-meshheading:10558914...lld:pubmed
pubmed-article:10558914pubmed:meshHeadingpubmed-meshheading:10558914...lld:pubmed
pubmed-article:10558914pubmed:meshHeadingpubmed-meshheading:10558914...lld:pubmed
pubmed-article:10558914pubmed:meshHeadingpubmed-meshheading:10558914...lld:pubmed
pubmed-article:10558914pubmed:year1999lld:pubmed
pubmed-article:10558914pubmed:articleTitleProtein synthesis inhibition by flavonoids: roles of eukaryotic initiation factor 2alpha kinases.lld:pubmed
pubmed-article:10558914pubmed:affiliationDepartment of Internal Medicine, University of Texas Medical Branch at Galveston, Galveston, Texas, 77555-1048, USA.lld:pubmed
pubmed-article:10558914pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:10558914pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10558914lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10558914lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10558914lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10558914lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10558914lld:pubmed