| pubmed-article:10556828 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10556828 | lifeskim:mentions | umls-concept:C1367453 | lld:lifeskim |
| pubmed-article:10556828 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:10556828 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:10556828 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:10556828 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:10556828 | lifeskim:mentions | umls-concept:C1516044 | lld:lifeskim |
| pubmed-article:10556828 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:10556828 | pubmed:dateCreated | 1999-12-23 | lld:pubmed |
| pubmed-article:10556828 | pubmed:abstractText | Nur77 is a transcription factor that is induced to a high level during TCR-mediated apoptosis of thymocytes and T cell hybridomas. Expression of a dominant-negative mutant of Nur77 can inhibit TCR-mediated apoptosis, while constitutive expression of full-length Nur77 in thymocytes leads to massive apoptosis. Nur77 is similar to the steroid receptor family and consists of a transactivation, a DNA-binding and a C-terminal "ligand-binding" domain. In contrast to the other nuclear receptors, Nur77 activity does not appear to depend on any ligand. However, its C-terminal region can regulate its transactivation activity. A short C-terminal deletion results in a protein with only 15 - 20% activity while deletion of the entire C-terminal region increases its activity. To further study the role of Nur77 transcription in apoptosis, we have generated transgenic mice expressing Nur77 with a short C-terminal deletion or Nur77 without its entire C-terminal domain. Mice expressing the shorter deletion/transcriptionally less active mutant displayed a mild phenotype. However, mice with the larger deletion/more transcriptionally active mutant showed massive thymocyte apoptosis. These data suggest that Nur77 transcription correlates with its apoptotic function in vivo. | lld:pubmed |
| pubmed-article:10556828 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10556828 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10556828 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10556828 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10556828 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10556828 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10556828 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10556828 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10556828 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10556828 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10556828 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:10556828 | pubmed:issn | 0014-2980 | lld:pubmed |
| pubmed-article:10556828 | pubmed:author | pubmed-author:CadiNN | lld:pubmed |
| pubmed-article:10556828 | pubmed:author | pubmed-author:WinotoAA | lld:pubmed |
| pubmed-article:10556828 | pubmed:author | pubmed-author:KuangA AAA | lld:pubmed |
| pubmed-article:10556828 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10556828 | pubmed:volume | 29 | lld:pubmed |
| pubmed-article:10556828 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10556828 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10556828 | pubmed:pagination | 3722-8 | lld:pubmed |
| pubmed-article:10556828 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:10556828 | pubmed:meshHeading | pubmed-meshheading:10556828... | lld:pubmed |
| pubmed-article:10556828 | pubmed:meshHeading | pubmed-meshheading:10556828... | lld:pubmed |
| pubmed-article:10556828 | pubmed:meshHeading | pubmed-meshheading:10556828... | lld:pubmed |
| pubmed-article:10556828 | pubmed:meshHeading | pubmed-meshheading:10556828... | lld:pubmed |
| pubmed-article:10556828 | pubmed:meshHeading | pubmed-meshheading:10556828... | lld:pubmed |
| pubmed-article:10556828 | pubmed:meshHeading | pubmed-meshheading:10556828... | lld:pubmed |
| pubmed-article:10556828 | pubmed:meshHeading | pubmed-meshheading:10556828... | lld:pubmed |
| pubmed-article:10556828 | pubmed:meshHeading | pubmed-meshheading:10556828... | lld:pubmed |
| pubmed-article:10556828 | pubmed:meshHeading | pubmed-meshheading:10556828... | lld:pubmed |
| pubmed-article:10556828 | pubmed:meshHeading | pubmed-meshheading:10556828... | lld:pubmed |
| pubmed-article:10556828 | pubmed:meshHeading | pubmed-meshheading:10556828... | lld:pubmed |
| pubmed-article:10556828 | pubmed:meshHeading | pubmed-meshheading:10556828... | lld:pubmed |
| pubmed-article:10556828 | pubmed:meshHeading | pubmed-meshheading:10556828... | lld:pubmed |
| pubmed-article:10556828 | pubmed:meshHeading | pubmed-meshheading:10556828... | lld:pubmed |
| pubmed-article:10556828 | pubmed:meshHeading | pubmed-meshheading:10556828... | lld:pubmed |
| pubmed-article:10556828 | pubmed:meshHeading | pubmed-meshheading:10556828... | lld:pubmed |
| pubmed-article:10556828 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10556828 | pubmed:articleTitle | Nur77 transcription activity correlates with its apoptotic function in vivo. | lld:pubmed |
| pubmed-article:10556828 | pubmed:affiliation | Department of Molecular Biology, Division of Immunology and Cancer Research Laboratory, 469 LSA, University of California at Berkeley, Berkeley, USA. | lld:pubmed |
| pubmed-article:10556828 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10556828 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10556828 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:10556828 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10556828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10556828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10556828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10556828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10556828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10556828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10556828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10556828 | lld:pubmed |
