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pubmed-article:10551903pubmed:abstractTextProduction of transgenic pigs for multiple transgenes is part of a potential strategy to prevent immunological events involved in xenograft rejection. Use of a genetically engineerable rodent as a donor in primates could allow testing in vivo of the effects of different transgenes on controlling xenograft rejection. As a first step in the development of a donor containing multiple transgenes, transgenic rats for human decay-accelerating factor (DAF) were used as heart donors to test their resistance against complement (C)-mediated rejection by non-human primates.lld:pubmed
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pubmed-article:10551903pubmed:articleTitleProtection against hyperacute xenograft rejection of transgenic rat hearts expressing human decay accelerating factor (DAF) transplanted into primates.lld:pubmed
pubmed-article:10551903pubmed:affiliationINSERM U437 "Immunointervention en Allo et Xénotransplantation" and Institut de Transplantation et de Recherche en Transplantation, Nantes, France.lld:pubmed
pubmed-article:10551903pubmed:publicationTypeJournal Articlelld:pubmed
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