| pubmed-article:10551366 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10551366 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:10551366 | lifeskim:mentions | umls-concept:C0032150 | lld:lifeskim |
| pubmed-article:10551366 | lifeskim:mentions | umls-concept:C1519249 | lld:lifeskim |
| pubmed-article:10551366 | lifeskim:mentions | umls-concept:C0679058 | lld:lifeskim |
| pubmed-article:10551366 | lifeskim:mentions | umls-concept:C1547699 | lld:lifeskim |
| pubmed-article:10551366 | lifeskim:mentions | umls-concept:C2700640 | lld:lifeskim |
| pubmed-article:10551366 | lifeskim:mentions | umls-concept:C1880371 | lld:lifeskim |
| pubmed-article:10551366 | lifeskim:mentions | umls-concept:C0758506 | lld:lifeskim |
| pubmed-article:10551366 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:10551366 | pubmed:dateCreated | 1999-12-23 | lld:pubmed |
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| pubmed-article:10551366 | pubmed:abstractText | The gene encoding merozoite surface protein 5 (MSP5) of Plasmodium falciparum is situated between the genes encoding MSP2 and MSP4 on chromosome 2. Both MSP4 and MSP5 encode proteins that contain hydrophobic signal and glycosylphosphatidylinositol (GPI) attachment signals and a single epidermal growth factor (EGF)-like domain at their carboxyl termini. The similar gene organization, location and similar structural features of the two genes suggest that they have arisen from a gene duplication event. In this study we provide further evidence for the merozoite surface location of MSP5 by demonstrating that MSP5 is present in isolated merozoites, partitions in the detergent-enriched phase following Triton X-114 fractionation and shows a staining pattern consistent with merozoite surface location by indirect immunofluorescence confocal microscopy. Analysis of antigenic diversity of MSP5 shows a lack of sequence variation between various isolates of P. falciparum from different geographical locations, a feature unusual for surface proteins of merozoites and one that may simplify vaccine formulation. | lld:pubmed |
| pubmed-article:10551366 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10551366 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10551366 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10551366 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10551366 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10551366 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10551366 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:10551366 | pubmed:issn | 0166-6851 | lld:pubmed |
| pubmed-article:10551366 | pubmed:author | pubmed-author:WangLL | lld:pubmed |
| pubmed-article:10551366 | pubmed:author | pubmed-author:WuTT | lld:pubmed |
| pubmed-article:10551366 | pubmed:author | pubmed-author:BlackC GCG | lld:pubmed |
| pubmed-article:10551366 | pubmed:author | pubmed-author:CoppelR LRL | lld:pubmed |
| pubmed-article:10551366 | pubmed:author | pubmed-author:HibbsA RAR | lld:pubmed |
| pubmed-article:10551366 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10551366 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:10551366 | pubmed:volume | 103 | lld:pubmed |
| pubmed-article:10551366 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10551366 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10551366 | pubmed:pagination | 243-50 | lld:pubmed |
| pubmed-article:10551366 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:10551366 | pubmed:meshHeading | pubmed-meshheading:10551366... | lld:pubmed |
| pubmed-article:10551366 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10551366 | pubmed:articleTitle | Lack of sequence diversity in the gene encoding merozoite surface protein 5 of Plasmodium falciparum. | lld:pubmed |
| pubmed-article:10551366 | pubmed:affiliation | Department of Microbiology, Monash University, Clayton, Vic., Australia. | lld:pubmed |
| pubmed-article:10551366 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10551366 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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