| pubmed-article:10544245 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10544245 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:10544245 | lifeskim:mentions | umls-concept:C0215848 | lld:lifeskim |
| pubmed-article:10544245 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:10544245 | lifeskim:mentions | umls-concept:C2348977 | lld:lifeskim |
| pubmed-article:10544245 | lifeskim:mentions | umls-concept:C1822686 | lld:lifeskim |
| pubmed-article:10544245 | lifeskim:mentions | umls-concept:C2348110 | lld:lifeskim |
| pubmed-article:10544245 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:10544245 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:10544245 | pubmed:dateCreated | 1999-12-10 | lld:pubmed |
| pubmed-article:10544245 | pubmed:abstractText | The protein chaperone heat shock protein 90 (Hsp90) is a major regulator of different transcription factors such as MyoD, a basic helix loop helix (bHLH) protein, and the bHLH-Per-aryl hydrocarbon nuclear translocator (ARNT)-Sim (PAS) factors Sim and aryl hydrocarbon receptor (Ahr). The transcription factor hypoxia-inducible factor-1alpha (HIF-1alpha), involved in the response to hypoxia, also belongs to the bHLH-PAS family. This work was aimed to investigate the putative role of Hsp90 in HIF-1 activation by hypoxia. Using a EGFP-HIF-1alpha fusion protein, co-immunoprecipitation experiments evidenced that the chimeric protein expressed in COS-7 cells interacts with Hsp90 in normoxia but not in hypoxia. We also demonstrated that Hsp90 interacts with the bHLH-PAS domain of HIF-1alpha. Moreover, Hsp90 is not co-translocated with HIF-1alpha into the nucleus. At last, we showed that Hsp90 activity is essential for HIF-1 activation in hypoxia since it is inhibited in the presence of geldanamycin. These results indicate that Hsp90 is a major regulator in HIF-1alpha activation. | lld:pubmed |
| pubmed-article:10544245 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10544245 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10544245 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10544245 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10544245 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10544245 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10544245 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10544245 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10544245 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10544245 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10544245 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10544245 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:10544245 | pubmed:issn | 0014-5793 | lld:pubmed |
| pubmed-article:10544245 | pubmed:author | pubmed-author:MichelGG | lld:pubmed |
| pubmed-article:10544245 | pubmed:author | pubmed-author:RemacleJJ | lld:pubmed |
| pubmed-article:10544245 | pubmed:author | pubmed-author:RolandII | lld:pubmed |
| pubmed-article:10544245 | pubmed:author | pubmed-author:RaesMM | lld:pubmed |
| pubmed-article:10544245 | pubmed:author | pubmed-author:MichielsCC | lld:pubmed |
| pubmed-article:10544245 | pubmed:author | pubmed-author:MottetDD | lld:pubmed |
| pubmed-article:10544245 | pubmed:author | pubmed-author:MinesDD | lld:pubmed |
| pubmed-article:10544245 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10544245 | pubmed:day | 29 | lld:pubmed |
| pubmed-article:10544245 | pubmed:volume | 460 | lld:pubmed |
| pubmed-article:10544245 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10544245 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10544245 | pubmed:pagination | 251-6 | lld:pubmed |
| pubmed-article:10544245 | pubmed:dateRevised | 2005-11-17 | lld:pubmed |
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| pubmed-article:10544245 | pubmed:meshHeading | pubmed-meshheading:10544245... | lld:pubmed |
| pubmed-article:10544245 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10544245 | pubmed:articleTitle | Hypoxia-induced activation of HIF-1: role of HIF-1alpha-Hsp90 interaction. | lld:pubmed |
| pubmed-article:10544245 | pubmed:affiliation | Laboratoire de Biochimie et Biologie Cellulaire, Facultés Universitaires de la Paix, 61 rue de Bruxelles, 5000, Namur, Belgium. emmanuel.minet@fundp.ac.be | lld:pubmed |
| pubmed-article:10544245 | pubmed:publicationType | Journal Article | lld:pubmed |
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