| pubmed-article:10543731 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10543731 | lifeskim:mentions | umls-concept:C0242692 | lld:lifeskim |
| pubmed-article:10543731 | lifeskim:mentions | umls-concept:C0949649 | lld:lifeskim |
| pubmed-article:10543731 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
| pubmed-article:10543731 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:10543731 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:10543731 | lifeskim:mentions | umls-concept:C1412925 | lld:lifeskim |
| pubmed-article:10543731 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:10543731 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:10543731 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:10543731 | lifeskim:mentions | umls-concept:C1511938 | lld:lifeskim |
| pubmed-article:10543731 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:10543731 | pubmed:dateCreated | 1999-11-22 | lld:pubmed |
| pubmed-article:10543731 | pubmed:abstractText | SM-20 is a novel, evolutionarily conserved "early response" gene originally cloned from a rat aortic smooth muscle cell (SMC) cDNA library. SM-20 encodes a cytoplasmic protein, which is induced by platelet-derived growth factor and angiotensin II in cultured SMC and is upregulated in intimal SMC of atherosclerotic plaques and injured arteries. We have now examined SM-20 expression during differentiation of cultured skeletal myoblasts and during skeletal myogenesis in vivo. Low levels of SM-20 mRNA and protein were expressed in proliferating mouse C2C12 myoblasts. Differentiation by serum withdrawal was associated with a marked induction of SM-20 mRNA and the expression of high levels of SM-20 antigen in myotubes. The induction was partially inhibited by blocking differentiation with bFGF or TGFbeta. Similar results were obtained with the nonfusing mouse C25 myoblast line, suggesting that SM-20 upregulation is a consequence of biochemical differentiation and is fusion independent. During mouse embryogenesis, SM-20 was first observed at 8.5E in the dermomyotomal cells of the rostral somites. SM-20 expression progressed in a rostral to caudal pattern, with highest levels seen in the muscle primordia and mature muscles. SM-20 thus represents a novel intracellular protein that is regulated during skeletal muscle differentiation and development. | lld:pubmed |
| pubmed-article:10543731 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10543731 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10543731 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10543731 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10543731 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10543731 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10543731 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10543731 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10543731 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10543731 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10543731 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10543731 | pubmed:issn | 1052-2166 | lld:pubmed |
| pubmed-article:10543731 | pubmed:author | pubmed-author:TaubmanM BMB | lld:pubmed |
| pubmed-article:10543731 | pubmed:author | pubmed-author:TsanMM | lld:pubmed |
| pubmed-article:10543731 | pubmed:author | pubmed-author:MenziesKK | lld:pubmed |
| pubmed-article:10543731 | pubmed:author | pubmed-author:KohtzD SDS | lld:pubmed |
| pubmed-article:10543731 | pubmed:author | pubmed-author:MoschellaM... | lld:pubmed |
| pubmed-article:10543731 | pubmed:author | pubmed-author:KohtzJ DJD | lld:pubmed |
| pubmed-article:10543731 | pubmed:author | pubmed-author:LiebM AMA | lld:pubmed |
| pubmed-article:10543731 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10543731 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:10543731 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10543731 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10543731 | pubmed:pagination | 59-66 | lld:pubmed |
| pubmed-article:10543731 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:10543731 | pubmed:meshHeading | pubmed-meshheading:10543731... | lld:pubmed |
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| pubmed-article:10543731 | pubmed:meshHeading | pubmed-meshheading:10543731... | lld:pubmed |
| pubmed-article:10543731 | pubmed:meshHeading | pubmed-meshheading:10543731... | lld:pubmed |
| pubmed-article:10543731 | pubmed:meshHeading | pubmed-meshheading:10543731... | lld:pubmed |
| pubmed-article:10543731 | pubmed:meshHeading | pubmed-meshheading:10543731... | lld:pubmed |
| pubmed-article:10543731 | pubmed:meshHeading | pubmed-meshheading:10543731... | lld:pubmed |
| pubmed-article:10543731 | pubmed:meshHeading | pubmed-meshheading:10543731... | lld:pubmed |
| pubmed-article:10543731 | pubmed:meshHeading | pubmed-meshheading:10543731... | lld:pubmed |
| pubmed-article:10543731 | pubmed:meshHeading | pubmed-meshheading:10543731... | lld:pubmed |
| pubmed-article:10543731 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10543731 | pubmed:articleTitle | SM-20 is a novel growth factor-responsive gene regulated during skeletal muscle development and differentiation. | lld:pubmed |
| pubmed-article:10543731 | pubmed:affiliation | The Michael A. and Zena Wiener Cardiovascular Institute, Department of Medicine, The Mount Sinai School of Medicine, New York, NY 10029, USA. | lld:pubmed |
| pubmed-article:10543731 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10543731 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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