| pubmed-article:10540322 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10540322 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:10540322 | lifeskim:mentions | umls-concept:C0599779 | lld:lifeskim |
| pubmed-article:10540322 | lifeskim:mentions | umls-concept:C0019733 | lld:lifeskim |
| pubmed-article:10540322 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:10540322 | lifeskim:mentions | umls-concept:C0679199 | lld:lifeskim |
| pubmed-article:10540322 | lifeskim:mentions | umls-concept:C0456387 | lld:lifeskim |
| pubmed-article:10540322 | lifeskim:mentions | umls-concept:C1709630 | lld:lifeskim |
| pubmed-article:10540322 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:10540322 | pubmed:dateCreated | 1999-11-16 | lld:pubmed |
| pubmed-article:10540322 | pubmed:abstractText | H-2 class I-negative, HLA-A2.1-transgenic HHD mice were used for a comparative evaluation of the immunogenicity of HLA-A2.1-restricted human tumor-associated cytotoxic T lymphocyte (CTL) epitopes. A hierarchy was established among these peptides injected into mice in incomplete Freund's adjuvant which correlates globally with their capacity to bind and stabilize HLA-A2.1 molecules. Co-injection of a helper peptide enhanced most CTL responses. In contrast, classical HLA class I-transgenic mice which still express their own class I molecules did not, in most cases, develop HLA-A2.1-restricted CTL responses under the same experimental conditions. Different monoepitope immunization strategies of acceptable clinical usage were compared in HHD mice. Recombinant Ty-virus-like particles, or DNA encoding epitopes fused to the hepatitis B virus middle envelope protein gave the best results. Using this latter approach and a melanoma-based polyepitope construct, CTL responses against five distinct epitopes could be elicited simultaneously in a single animal. Thus, HHD mice provide a versatile animal model for preclinical evaluation of peptide-based cancer immunotherapy. | lld:pubmed |
| pubmed-article:10540322 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10540322 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10540322 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10540322 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10540322 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10540322 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10540322 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:10540322 | pubmed:issn | 0014-2980 | lld:pubmed |
| pubmed-article:10540322 | pubmed:author | pubmed-author:JungGG | lld:pubmed |
| pubmed-article:10540322 | pubmed:author | pubmed-author:MichelM LML | lld:pubmed |
| pubmed-article:10540322 | pubmed:author | pubmed-author:GarciaZZ | lld:pubmed |
| pubmed-article:10540322 | pubmed:author | pubmed-author:JackR WRW | lld:pubmed |
| pubmed-article:10540322 | pubmed:author | pubmed-author:MateoLL | lld:pubmed |
| pubmed-article:10540322 | pubmed:author | pubmed-author:Langlade-Demo... | lld:pubmed |
| pubmed-article:10540322 | pubmed:author | pubmed-author:Kosmatopoulos... | lld:pubmed |
| pubmed-article:10540322 | pubmed:author | pubmed-author:SuhrbierAA | lld:pubmed |
| pubmed-article:10540322 | pubmed:author | pubmed-author:FiratHH | lld:pubmed |
| pubmed-article:10540322 | pubmed:author | pubmed-author:PascoloSS | lld:pubmed |
| pubmed-article:10540322 | pubmed:author | pubmed-author:LemonnierF... | lld:pubmed |
| pubmed-article:10540322 | pubmed:author | pubmed-author:Garcia-PonsFF | lld:pubmed |
| pubmed-article:10540322 | pubmed:author | pubmed-author:ScardinoAA | lld:pubmed |
| pubmed-article:10540322 | pubmed:author | pubmed-author:TourdotSS | lld:pubmed |
| pubmed-article:10540322 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10540322 | pubmed:volume | 29 | lld:pubmed |
| pubmed-article:10540322 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10540322 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10540322 | pubmed:pagination | 3112-21 | lld:pubmed |
| pubmed-article:10540322 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:10540322 | pubmed:meshHeading | pubmed-meshheading:10540322... | lld:pubmed |
| pubmed-article:10540322 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10540322 | pubmed:articleTitle | H-2 class I knockout, HLA-A2.1-transgenic mice: a versatile animal model for preclinical evaluation of antitumor immunotherapeutic strategies. | lld:pubmed |
| pubmed-article:10540322 | pubmed:affiliation | Unité d'Immunité Cellulaire Antivirale, Département SIDA-Rétrovirus, Institut Pasteur, Paris, France. hfirat@pasteur.fr | lld:pubmed |
| pubmed-article:10540322 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10540322 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:10540322 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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