| pubmed-article:10531256 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10531256 | lifeskim:mentions | umls-concept:C0006013 | lld:lifeskim |
| pubmed-article:10531256 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:10531256 | lifeskim:mentions | umls-concept:C0596402 | lld:lifeskim |
| pubmed-article:10531256 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:10531256 | lifeskim:mentions | umls-concept:C0332257 | lld:lifeskim |
| pubmed-article:10531256 | lifeskim:mentions | umls-concept:C0851827 | lld:lifeskim |
| pubmed-article:10531256 | lifeskim:mentions | umls-concept:C1701901 | lld:lifeskim |
| pubmed-article:10531256 | lifeskim:mentions | umls-concept:C0136166 | lld:lifeskim |
| pubmed-article:10531256 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:10531256 | pubmed:dateCreated | 1999-11-16 | lld:pubmed |
| pubmed-article:10531256 | pubmed:abstractText | The effect of Bordetella bronchiseptica infection on the viability of murine macrophage-like cells and on primary porcine alveolar macrophages was investigated. The bacterium was shown to be cytotoxic for both cell types, particularly where tight cell-to-cell contacts were established. In addition, bvg mutants were poorly cytotoxic for the eukaryotic cells, while a prn mutant was significantly less toxic than wild-type bacteria. B. bronchiseptica-mediated cytotoxicity was inhibited in the presence of cytochalasin D or cycloheximide, an inhibitor of microfilament-dependent phagocytosis or de novo eukaryotic protein synthesis, respectively. The mechanism of eukaryotic cell death was examined, and cell death was found to occur primarily through a necrotic pathway, although a small proportion of the population underwent apoptosis. | lld:pubmed |
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| pubmed-article:10531256 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10531256 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10531256 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10531256 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10531256 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:10531256 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:10531256 | pubmed:author | pubmed-author:RobertsMM | lld:pubmed |
| pubmed-article:10531256 | pubmed:author | pubmed-author:OOIS KSK | lld:pubmed |
| pubmed-article:10531256 | pubmed:author | pubmed-author:ShiXX | lld:pubmed |
| pubmed-article:10531256 | pubmed:author | pubmed-author:FordeC BCB | lld:pubmed |
| pubmed-article:10531256 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10531256 | pubmed:volume | 67 | lld:pubmed |
| pubmed-article:10531256 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10531256 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10531256 | pubmed:pagination | 5972-8 | lld:pubmed |
| pubmed-article:10531256 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:10531256 | pubmed:meshHeading | pubmed-meshheading:10531256... | lld:pubmed |
| pubmed-article:10531256 | pubmed:meshHeading | pubmed-meshheading:10531256... | lld:pubmed |
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| pubmed-article:10531256 | pubmed:meshHeading | pubmed-meshheading:10531256... | lld:pubmed |
| pubmed-article:10531256 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10531256 | pubmed:articleTitle | Bordetella bronchiseptica-mediated cytotoxicity to macrophages is dependent on bvg-regulated factors, including pertactin. | lld:pubmed |
| pubmed-article:10531256 | pubmed:affiliation | Department of Veterinary Pathology, University of Glasgow Veterinary School, Garscube Estate, Glasgow G61 1QH, Scotland. | lld:pubmed |
| pubmed-article:10531256 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10531256 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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