| pubmed-article:1052769 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1052769 | lifeskim:mentions | umls-concept:C0205474 | lld:lifeskim |
| pubmed-article:1052769 | lifeskim:mentions | umls-concept:C0205419 | lld:lifeskim |
| pubmed-article:1052769 | lifeskim:mentions | umls-concept:C1522021 | lld:lifeskim |
| pubmed-article:1052769 | lifeskim:mentions | umls-concept:C1457869 | lld:lifeskim |
| pubmed-article:1052769 | lifeskim:mentions | umls-concept:C0314603 | lld:lifeskim |
| pubmed-article:1052769 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:1052769 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:1052769 | pubmed:dateCreated | 1978-12-20 | lld:pubmed |
| pubmed-article:1052769 | pubmed:abstractText | The surface proteins of Thy-1 positive mouse lymphomas and Thy-1 negative variants were labeled by lactoperoxidase-catalyzed iodination and characterized by polyacrylamide gel electrophoresis in the presence of sodium dodecylsulphate and by immunological studies. The loss of the serologically defined Thy-1 antigenic determinant correlated with the absence of a radioactive band corresponding to a T lymphocyte-specific surface glycoprotein, T25, on autoradiographs of the iodinated proteins of Thy-1 negative variants. Reexpression of Thy-1 on hybrid cells dervied from fusions of complementary Thy-1 negative variants correlated with the reappearance of T25. Quantitative absorption studies using an antiserum which specifically recognized T25 confirmed that the Thy-1 negative variants have no detectable T25 (less than 0.03 of that of the Thy-1 positive lines) on their surface. Biosynthetic labeling studies revealed that none of the Thy-1 negative variants synthesized T25. However, synthesis of an immunologically cross-reactive molecule could be detected in two variants. On the basis of these results, we propose a model which describes a possible structure of the Thy-1 antigenic determinant and explains the biochemical nature of the genetic lesions leading to the loss of Thy-1 in these variants. | lld:pubmed |
| pubmed-article:1052769 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1052769 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1052769 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1052769 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1052769 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1052769 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1052769 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:1052769 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:1052769 | pubmed:author | pubmed-author:TrowbridgeI... | lld:pubmed |
| pubmed-article:1052769 | pubmed:author | pubmed-author:HymanRR | lld:pubmed |
| pubmed-article:1052769 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1052769 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:1052769 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1052769 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1052769 | pubmed:pagination | 279-87 | lld:pubmed |
| pubmed-article:1052769 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1052769 | pubmed:meshHeading | pubmed-meshheading:1052769-... | lld:pubmed |
| pubmed-article:1052769 | pubmed:meshHeading | pubmed-meshheading:1052769-... | lld:pubmed |
| pubmed-article:1052769 | pubmed:meshHeading | pubmed-meshheading:1052769-... | lld:pubmed |
| pubmed-article:1052769 | pubmed:meshHeading | pubmed-meshheading:1052769-... | lld:pubmed |
| pubmed-article:1052769 | pubmed:meshHeading | pubmed-meshheading:1052769-... | lld:pubmed |
| pubmed-article:1052769 | pubmed:meshHeading | pubmed-meshheading:1052769-... | lld:pubmed |
| pubmed-article:1052769 | pubmed:meshHeading | pubmed-meshheading:1052769-... | lld:pubmed |
| pubmed-article:1052769 | pubmed:year | 1975 | lld:pubmed |
| pubmed-article:1052769 | pubmed:articleTitle | Thy-1 variants of mouse lymphomas: biochemical characterization of the genetic defect. | lld:pubmed |
| pubmed-article:1052769 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1052769 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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