| pubmed-article:10523842 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10523842 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:10523842 | lifeskim:mentions | umls-concept:C0029016 | lld:lifeskim |
| pubmed-article:10523842 | lifeskim:mentions | umls-concept:C0040711 | lld:lifeskim |
| pubmed-article:10523842 | lifeskim:mentions | umls-concept:C0812222 | lld:lifeskim |
| pubmed-article:10523842 | lifeskim:mentions | umls-concept:C0079941 | lld:lifeskim |
| pubmed-article:10523842 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:10523842 | pubmed:issue | 41 | lld:pubmed |
| pubmed-article:10523842 | pubmed:dateCreated | 1999-11-22 | lld:pubmed |
| pubmed-article:10523842 | pubmed:abstractText | Overexpression of oncoprotein MDM2 has been found in a significant number of human soft tissue tumors. In a subset of these tumors, overexpression is a result of enhanced translation of mdm2 mRNA. There are two transcripts from the mdm2 gene that differ only in their 5' leaders: a long form (L-mdm2) and a short form (S-mdm2) that arise from the use of different promoters. L-mdm2 mRNA contains two upstream open reading frames (uORFs) and this mRNA was loaded with ribosomes inefficiently in comparison with S-mdm2. The 5' leader of L-mdm2 was sufficient to transfer translational repression to a reporter gene and the two uORFs acted synergistically to achieve full suppression. In contrast, the 5' leader of S-mdm2 allowed efficient translation of an attached reporter gene in the tumor cells. These results are consistent with a model in which overexpression of MDM2 in certain tumors results from a change in mRNA structure due to a switch in promoter usage. | lld:pubmed |
| pubmed-article:10523842 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10523842 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10523842 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10523842 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10523842 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10523842 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10523842 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10523842 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10523842 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10523842 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10523842 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10523842 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10523842 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10523842 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:10523842 | pubmed:issn | 0950-9232 | lld:pubmed |
| pubmed-article:10523842 | pubmed:author | pubmed-author:MorrisD RDR | lld:pubmed |
| pubmed-article:10523842 | pubmed:author | pubmed-author:PinedaMM | lld:pubmed |
| pubmed-article:10523842 | pubmed:author | pubmed-author:GeorgeD LDL | lld:pubmed |
| pubmed-article:10523842 | pubmed:author | pubmed-author:BrownC YCY | lld:pubmed |
| pubmed-article:10523842 | pubmed:author | pubmed-author:MizeG JGJ | lld:pubmed |
| pubmed-article:10523842 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10523842 | pubmed:day | 7 | lld:pubmed |
| pubmed-article:10523842 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:10523842 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10523842 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10523842 | pubmed:pagination | 5631-7 | lld:pubmed |
| pubmed-article:10523842 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:10523842 | pubmed:meshHeading | pubmed-meshheading:10523842... | lld:pubmed |
| pubmed-article:10523842 | pubmed:meshHeading | pubmed-meshheading:10523842... | lld:pubmed |
| pubmed-article:10523842 | pubmed:meshHeading | pubmed-meshheading:10523842... | lld:pubmed |
| pubmed-article:10523842 | pubmed:meshHeading | pubmed-meshheading:10523842... | lld:pubmed |
| pubmed-article:10523842 | pubmed:meshHeading | pubmed-meshheading:10523842... | lld:pubmed |
| pubmed-article:10523842 | pubmed:meshHeading | pubmed-meshheading:10523842... | lld:pubmed |
| pubmed-article:10523842 | pubmed:meshHeading | pubmed-meshheading:10523842... | lld:pubmed |
| pubmed-article:10523842 | pubmed:meshHeading | pubmed-meshheading:10523842... | lld:pubmed |
| pubmed-article:10523842 | pubmed:meshHeading | pubmed-meshheading:10523842... | lld:pubmed |
| pubmed-article:10523842 | pubmed:meshHeading | pubmed-meshheading:10523842... | lld:pubmed |
| pubmed-article:10523842 | pubmed:meshHeading | pubmed-meshheading:10523842... | lld:pubmed |
| pubmed-article:10523842 | pubmed:meshHeading | pubmed-meshheading:10523842... | lld:pubmed |
| pubmed-article:10523842 | pubmed:meshHeading | pubmed-meshheading:10523842... | lld:pubmed |
| pubmed-article:10523842 | pubmed:meshHeading | pubmed-meshheading:10523842... | lld:pubmed |
| pubmed-article:10523842 | pubmed:meshHeading | pubmed-meshheading:10523842... | lld:pubmed |
| pubmed-article:10523842 | pubmed:meshHeading | pubmed-meshheading:10523842... | lld:pubmed |
| pubmed-article:10523842 | pubmed:meshHeading | pubmed-meshheading:10523842... | lld:pubmed |
| pubmed-article:10523842 | pubmed:meshHeading | pubmed-meshheading:10523842... | lld:pubmed |
| pubmed-article:10523842 | pubmed:meshHeading | pubmed-meshheading:10523842... | lld:pubmed |
| pubmed-article:10523842 | pubmed:meshHeading | pubmed-meshheading:10523842... | lld:pubmed |
| pubmed-article:10523842 | pubmed:meshHeading | pubmed-meshheading:10523842... | lld:pubmed |
| pubmed-article:10523842 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10523842 | pubmed:articleTitle | Role of two upstream open reading frames in the translational control of oncogene mdm2. | lld:pubmed |
| pubmed-article:10523842 | pubmed:affiliation | Department of Biochemistry, University of Washington, Seattle, Washington, WA 98195-7350, USA. | lld:pubmed |
| pubmed-article:10523842 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10523842 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10523842 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10523842 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10523842 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10523842 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10523842 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10523842 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10523842 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10523842 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10523842 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10523842 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10523842 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10523842 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10523842 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10523842 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10523842 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10523842 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10523842 | lld:pubmed |
