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| pubmed-article:10523317 | lifeskim:mentions | umls-concept:C0449438 | lld:lifeskim |
| pubmed-article:10523317 | lifeskim:mentions | umls-concept:C0598312 | lld:lifeskim |
| pubmed-article:10523317 | lifeskim:mentions | umls-concept:C0114615 | lld:lifeskim |
| pubmed-article:10523317 | lifeskim:mentions | umls-concept:C1519249 | lld:lifeskim |
| pubmed-article:10523317 | lifeskim:mentions | umls-concept:C0599894 | lld:lifeskim |
| pubmed-article:10523317 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:10523317 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:10523317 | lifeskim:mentions | umls-concept:C0442614 | lld:lifeskim |
| pubmed-article:10523317 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:10523317 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:10523317 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:10523317 | pubmed:issue | 20 | lld:pubmed |
| pubmed-article:10523317 | pubmed:dateCreated | 1999-12-6 | lld:pubmed |
| pubmed-article:10523317 | pubmed:abstractText | The recruitment of DNA ligase I to replication foci in S phase depends on a replication factory targeting sequence that also mediates the interaction with proliferating cell nuclear antigen (PCNA) in vitro. By exploiting a monoclonal antibody directed at a phospho-epitope, we demonstrate that Ser66 of DNA ligase I, which is part of a strong CKII consensus site, is phosphorylated in a cell cycle-dependent manner. After dephosphorylation in early G(1), the level of Ser66 phosphorylation is minimal in G(1), increases progressively in S and peaks in G(2)/M phase. The analysis of epitope-tagged DNA ligase I mutants demonstrates that dephosphorylation of Ser66 requires both the nuclear localization and the PCNA-binding site of the enzyme. Finally, we show that DNA ligase I and PCNA interact in vivo in G(1) and S phase but not in G(2)/M. We propose that dephosphorylation of Ser66 is part of a novel control mechanism to establish the pre-replicative form of DNA ligase I. | lld:pubmed |
| pubmed-article:10523317 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10523317 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10523317 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10523317 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10523317 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:10523317 | pubmed:issn | 0261-4189 | lld:pubmed |
| pubmed-article:10523317 | pubmed:author | pubmed-author:CiarrocchiGG | lld:pubmed |
| pubmed-article:10523317 | pubmed:author | pubmed-author:RossiRR | lld:pubmed |
| pubmed-article:10523317 | pubmed:author | pubmed-author:VillaAA | lld:pubmed |
| pubmed-article:10523317 | pubmed:author | pubmed-author:NegriCC | lld:pubmed |
| pubmed-article:10523317 | pubmed:author | pubmed-author:BiamontiGG | lld:pubmed |
| pubmed-article:10523317 | pubmed:author | pubmed-author:MontecuccoAA | lld:pubmed |
| pubmed-article:10523317 | pubmed:author | pubmed-author:ScovassiII | lld:pubmed |
| pubmed-article:10523317 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10523317 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:10523317 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:10523317 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10523317 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10523317 | pubmed:pagination | 5745-54 | lld:pubmed |
| pubmed-article:10523317 | pubmed:dateRevised | 2008-11-20 | lld:pubmed |
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| pubmed-article:10523317 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10523317 | pubmed:articleTitle | The replication factory targeting sequence/PCNA-binding site is required in G(1) to control the phosphorylation status of DNA ligase I. | lld:pubmed |
| pubmed-article:10523317 | pubmed:affiliation | Istituto di Genetica Biochimica ed Evoluzionistica, CNR, Via Abbiategrasso 207, 27100 Pavia, Italy. | lld:pubmed |
| pubmed-article:10523317 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10523317 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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