| pubmed-article:10518614 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10518614 | lifeskim:mentions | umls-concept:C0034845 | lld:lifeskim |
| pubmed-article:10518614 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:10518614 | lifeskim:mentions | umls-concept:C1335671 | lld:lifeskim |
| pubmed-article:10518614 | lifeskim:mentions | umls-concept:C1517598 | lld:lifeskim |
| pubmed-article:10518614 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:10518614 | pubmed:issue | 21 | lld:pubmed |
| pubmed-article:10518614 | pubmed:dateCreated | 1999-12-2 | lld:pubmed |
| pubmed-article:10518614 | pubmed:abstractText | Treatment with iron chelators mimics hypoxic induction of the hypoxia inducible factor (HIF-1) which activates transcription by binding to hypoxia responsive elements (HRE). We investigated whether HIF-1 is involved in transcriptional activation of the transferrin receptor (TfR), a membrane protein which mediates cellular iron uptake, in response to iron deprivation. The transcription rate of the TfR gene in isolated nuclei was up-regulated by treatment of Hep3B human hepatoma cells with the iron chelator desferrioxamine (DFO). The role of HIF-1 in the activation of TfR was indicated by the following observations: (i) DFO-dependent activation of a luciferase reporter gene in transfected Hep3B cells was mediated by a fragment of the human TfR promoter containing a putative HRE sequence; (ii) mutation of this sequence prevented stimulation of luciferase activity; (iii) binding to this sequence of HIF-1alpha, identified by competition experiments and supershift assays, was induced by DFO. Furthermore, in mouse hepatoma cells unable to assemble functional HIF-1, inducibility of TfR transcription by DFO was lost and TfR mRNA up-regulation was reduced. These results, which show the role of HIF-1 in the control of TfR gene expression in conditions of iron depletion, give insights into the mechanisms of transcriptional regulation which concur with the well-characterized post-transcriptional control of TfR expression to expand the extent of response to iron deficiency. | lld:pubmed |
| pubmed-article:10518614 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10518614 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10518614 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10518614 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10518614 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:10518614 | pubmed:issn | 1362-4962 | lld:pubmed |
| pubmed-article:10518614 | pubmed:author | pubmed-author:BianchiLL | lld:pubmed |
| pubmed-article:10518614 | pubmed:author | pubmed-author:CairoGG | lld:pubmed |
| pubmed-article:10518614 | pubmed:author | pubmed-author:TacchiniLL | lld:pubmed |
| pubmed-article:10518614 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:10518614 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:10518614 | pubmed:volume | 27 | lld:pubmed |
| pubmed-article:10518614 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10518614 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10518614 | pubmed:pagination | 4223-7 | lld:pubmed |
| pubmed-article:10518614 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:10518614 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10518614 | pubmed:articleTitle | HIF-1-mediated activation of transferrin receptor gene transcription by iron chelation. | lld:pubmed |
| pubmed-article:10518614 | pubmed:affiliation | Istituto di Patologia Generale and Istituto Scienze Mediche, IRCCS Ospedale Maggiore, Università di Milano, Italy. | lld:pubmed |
| pubmed-article:10518614 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10518614 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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