| pubmed-article:10518526 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10518526 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:10518526 | lifeskim:mentions | umls-concept:C0034809 | lld:lifeskim |
| pubmed-article:10518526 | lifeskim:mentions | umls-concept:C0040690 | lld:lifeskim |
| pubmed-article:10518526 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:10518526 | lifeskim:mentions | umls-concept:C0162493 | lld:lifeskim |
| pubmed-article:10518526 | lifeskim:mentions | umls-concept:C0919432 | lld:lifeskim |
| pubmed-article:10518526 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:10518526 | lifeskim:mentions | umls-concept:C0599894 | lld:lifeskim |
| pubmed-article:10518526 | pubmed:issue | 21 | lld:pubmed |
| pubmed-article:10518526 | pubmed:dateCreated | 1999-11-24 | lld:pubmed |
| pubmed-article:10518526 | pubmed:abstractText | The transforming growth factor-beta (TGF-beta) family of cytokines and glucocorticoids regulate diverse biological processes through modulating the expression of target genes. Here we report that glucocorticoid receptor (GR) represses TGF-beta transcriptional activation of the type-1 plasminogen activator inhibitor (PAI-1) gene in a ligand-dependent manner. Similarly, GR represses TGF-beta activation of the TGF-beta responsive sequence containing Smad3/4-binding sites. Using mammalian two-hybrid assays, we demonstrate that GR inhibits transcriptional activation by both Smad3 and Smad4 C-terminal activation domains. Finally, we show that GR interacts with Smad3 both in vitro and in vivo. These results suggest a molecular basis for the cross-regulation between glucocorticoid and TGF-beta signaling pathways. | lld:pubmed |
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| pubmed-article:10518526 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10518526 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10518526 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10518526 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10518526 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10518526 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:10518526 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:10518526 | pubmed:author | pubmed-author:GelehrterT... | lld:pubmed |
| pubmed-article:10518526 | pubmed:author | pubmed-author:TianXX | lld:pubmed |
| pubmed-article:10518526 | pubmed:author | pubmed-author:SongC ZCZ | lld:pubmed |
| pubmed-article:10518526 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10518526 | pubmed:day | 12 | lld:pubmed |
| pubmed-article:10518526 | pubmed:volume | 96 | lld:pubmed |
| pubmed-article:10518526 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10518526 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10518526 | pubmed:pagination | 11776-81 | lld:pubmed |
| pubmed-article:10518526 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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