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pubmed-article:10515561pubmed:abstractTextGap junction channels are important determinants of conduction in the heart and may play a central role in the development of lethal cardiac arrhythmias. The recent development of a Cx43-deficient mouse has raised fundamental questions about the role of specific connexin isoforms in intercellular communication in the heart. Although a homozygous null mutation of the Cx43 gene (Cx43-/-) is lethal, the heterozygous (Cx43+/-) animals survive to adulthood. Reports on the cardiac electrophysiologic phenotype of the Cx43+/- mice are contradictory. Thus, the effects of a null mutation of a single Cx43 allele require reevaluation.lld:pubmed
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pubmed-article:10515561pubmed:articleTitleCharacterization of conduction in the ventricles of normal and heterozygous Cx43 knockout mice using optical mapping.lld:pubmed
pubmed-article:10515561pubmed:affiliationDepartment of Pharmacology, SUNY Health Science Center at Syracuse, New York 13210, USA. morleyg@vax.cs.hscsyr.edulld:pubmed
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