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pubmed-article:10514307pubmed:abstractTextThe new cytotoxic monotetrahydrofuran Annonaceous acetogenins, annocherin (1) and a mixture of (2,4)-cis- and trans-annocherinones (2 and 3), were isolated from the bioactive methanolic extract of Annonacherimolia seeds. Compounds 1-3 each possess an unusual 7-carbonyl group. Their structures were established on the basis of chemical and spectral evidence. Compounds 1-3 showed significant toxicity in the brine shrimp lethality test and cytotoxicity for six human solid tumor cell lines, with selectivity for the renal cell line (A-498) at potencies equivalent to Adriamycin.lld:pubmed
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pubmed-article:10514307pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:10514307pubmed:articleTitleAnnocherin and (2,4)-cis- and trans-annocherinones, monotetrahydrofuran Annonaceous acetogenins with a C-7 carbonyl group from Annona cherimolia seeds.lld:pubmed
pubmed-article:10514307pubmed:affiliationDepartment of Pharmacy, College of Pharmacy, Catholic University of Taegu-Hyosung, Kyongsan, 712-702, Korea. woomh@cuth.cataegu.ac.krlld:pubmed
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