| pubmed-article:10508968 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10508968 | lifeskim:mentions | umls-concept:C0028630 | lld:lifeskim |
| pubmed-article:10508968 | lifeskim:mentions | umls-concept:C0004793 | lld:lifeskim |
| pubmed-article:10508968 | lifeskim:mentions | umls-concept:C0017428 | lld:lifeskim |
| pubmed-article:10508968 | lifeskim:mentions | umls-concept:C0919262 | lld:lifeskim |
| pubmed-article:10508968 | lifeskim:mentions | umls-concept:C1519316 | lld:lifeskim |
| pubmed-article:10508968 | lifeskim:mentions | umls-concept:C0439857 | lld:lifeskim |
| pubmed-article:10508968 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:10508968 | pubmed:dateCreated | 1999-11-30 | lld:pubmed |
| pubmed-article:10508968 | pubmed:abstractText | The vibrational spectra of four genomic and two synthetic DNAs, encompassing a wide range in base composition [poly(dA-dT). poly(dA-dT), 0% G + C; Clostridium perfringens DNA, 27% G + C; calf thymus DNA, 42% G + C; Escherichia coli DNA, 50% G + C; Micrococcus luteus DNA, 72% G + C; poly(dG-dC).poly(dG-dC), 100% G + C] (dA: deoxyadenosine; dG: deoxyguanosine; dC: deoxycytidine; dT: thymidine), have been analyzed using Raman difference methods of high sensitivity. The results show that the Raman signature of B DNA depends in detail upon both genomic base composition and sequence. Raman bands assigned to vibrational modes of the deoxyribose-phosphate backbone are among the most sensitive to base sequence, indicating that within the B family of conformations major differences occur in the backbone geometry of AT- and GC-rich domains. Raman bands assigned to in-plane vibrations of the purine and pyrimidine bases-particularly of A and T-exhibit large deviations from the patterns expected for random base distributions, establishing that Raman hypochromic effects in genomic DNA are also highly sequence dependent. The present study provides a basis for future use of Raman spectroscopy to analyze sequence-specific DNA-ligand interactions. The demonstration of sequence dependency in the Raman spectrum of genomic B DNA also implies the capability to distinguish genomic DNAs by means of their characteristic Raman signatures. | lld:pubmed |
| pubmed-article:10508968 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10508968 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10508968 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10508968 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10508968 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10508968 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10508968 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10508968 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10508968 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:10508968 | pubmed:issn | 0006-3525 | lld:pubmed |
| pubmed-article:10508968 | pubmed:author | pubmed-author:ThomasG JGJJr | lld:pubmed |
| pubmed-article:10508968 | pubmed:author | pubmed-author:BloomfieldV... | lld:pubmed |
| pubmed-article:10508968 | pubmed:author | pubmed-author:DengHH | lld:pubmed |
| pubmed-article:10508968 | pubmed:author | pubmed-author:BenevidesJ... | lld:pubmed |
| pubmed-article:10508968 | pubmed:copyrightInfo | Copyright 1999 John Wiley & Sons, Inc. | lld:pubmed |
| pubmed-article:10508968 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10508968 | pubmed:volume | 50 | lld:pubmed |
| pubmed-article:10508968 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10508968 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10508968 | pubmed:pagination | 656-66 | lld:pubmed |
| pubmed-article:10508968 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:10508968 | pubmed:meshHeading | pubmed-meshheading:10508968... | lld:pubmed |
| pubmed-article:10508968 | pubmed:meshHeading | pubmed-meshheading:10508968... | lld:pubmed |
| pubmed-article:10508968 | pubmed:meshHeading | pubmed-meshheading:10508968... | lld:pubmed |
| pubmed-article:10508968 | pubmed:meshHeading | pubmed-meshheading:10508968... | lld:pubmed |
| pubmed-article:10508968 | pubmed:meshHeading | pubmed-meshheading:10508968... | lld:pubmed |
| pubmed-article:10508968 | pubmed:meshHeading | pubmed-meshheading:10508968... | lld:pubmed |
| pubmed-article:10508968 | pubmed:meshHeading | pubmed-meshheading:10508968... | lld:pubmed |
| pubmed-article:10508968 | pubmed:meshHeading | pubmed-meshheading:10508968... | lld:pubmed |
| pubmed-article:10508968 | pubmed:meshHeading | pubmed-meshheading:10508968... | lld:pubmed |
| pubmed-article:10508968 | pubmed:meshHeading | pubmed-meshheading:10508968... | lld:pubmed |
| pubmed-article:10508968 | pubmed:meshHeading | pubmed-meshheading:10508968... | lld:pubmed |
| pubmed-article:10508968 | pubmed:meshHeading | pubmed-meshheading:10508968... | lld:pubmed |
| pubmed-article:10508968 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10508968 | pubmed:articleTitle | Dependence of the Raman signature of genomic B-DNA on nucleotide base sequence. | lld:pubmed |
| pubmed-article:10508968 | pubmed:affiliation | Department of Biochemistry, University of Minnesota, St. Paul, MN 55108, USA. | lld:pubmed |
| pubmed-article:10508968 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10508968 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:10508968 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10508968 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10508968 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10508968 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10508968 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10508968 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10508968 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10508968 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10508968 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10508968 | lld:pubmed |
