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pubmed-article:10508788pubmed:abstractTextMitogen-activated protein (MAP) kinases mediate the cellular response to stimuli such as pro-inflammatory cytokines and environmental stress. P38gamma is a new member of the MAP kinase family, and is expressed at its highest levels in skeletal muscle. P38gamma is 63% identical in sequence to P38alpha. The structure of P38alpha MAP kinase has been determined in the apo, unphosphorylated, inactive form. The structures of apo unphosphorylated ERK2, a related MAP kinase, and apo phosphorylated ERK2 have also been determined.lld:pubmed
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pubmed-article:10508788pubmed:articleTitleThe structure of phosphorylated p38gamma is monomeric and reveals a conserved activation-loop conformation.lld:pubmed
pubmed-article:10508788pubmed:affiliationVertex Pharmaceuticals Incorporated 130 Waverly Street, Cambridge, MA 02139-4211, USA. bellon@vpharm.com.lld:pubmed
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