| pubmed-article:10508587 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10508587 | lifeskim:mentions | umls-concept:C0008633 | lld:lifeskim |
| pubmed-article:10508587 | lifeskim:mentions | umls-concept:C0733755 | lld:lifeskim |
| pubmed-article:10508587 | lifeskim:mentions | umls-concept:C0079429 | lld:lifeskim |
| pubmed-article:10508587 | lifeskim:mentions | umls-concept:C1521828 | lld:lifeskim |
| pubmed-article:10508587 | lifeskim:mentions | umls-concept:C0392760 | lld:lifeskim |
| pubmed-article:10508587 | pubmed:issue | 17 | lld:pubmed |
| pubmed-article:10508587 | pubmed:dateCreated | 2000-1-4 | lld:pubmed |
| pubmed-article:10508587 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10508587 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10508587 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10508587 | pubmed:abstractText | Genes evolve at different rates depending on the strength of selective pressure to maintain their function. Chromosomal position can also have an influence [1] [2]. The pseudoautosomal region (PAR) of mammalian sex chromosomes is a small region of sequence identity that is the site of an obligatory pairing and recombination event between the X and Y chromosomes during male meiosis [3] [4] [5] [6]. During female meiosis, X chromosomes can pair and recombine along their entire length. Recombination in the PAR is therefore approximately 10 times greater in male meiosis compared with female meiosis [4] [5] [6]. The gene Fxy (also known as MID1 [7]) spans the pseudoautosomal boundary (PAB) in the laboratory mouse (Mus musculus domesticus, C57BL/6) such that the 5' three exons of the gene are located on the X chromosome but the seven exons encoding the carboxy-terminal two-thirds of the protein are located within the PAR and are therefore present on both the X and Y chromosomes [8]. In humans [7] [9], the rat, and the wild mouse species Mus spretus, the gene is entirely X-unique. Here, we report that the rate of sequence divergence of the 3' end of the Fxy gene is much higher (estimated at 170-fold higher for synonymous sites) when pseudoautosomal (present on both the X and Y chromosomes) than when X-unique. Thus, chromosomal position can directly affect the rate of evolution of a gene. This finding also provides support for the suggestion that regions of the genome with a high recombination frequency, such as the PAR, may have an intrinsically elevated rate of sequence divergence. | lld:pubmed |
| pubmed-article:10508587 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10508587 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10508587 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10508587 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10508587 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10508587 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:10508587 | pubmed:issn | 0960-9822 | lld:pubmed |
| pubmed-article:10508587 | pubmed:author | pubmed-author:PerryJJ | lld:pubmed |
| pubmed-article:10508587 | pubmed:author | pubmed-author:AshworthAA | lld:pubmed |
| pubmed-article:10508587 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10508587 | pubmed:day | 9 | lld:pubmed |
| pubmed-article:10508587 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:10508587 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10508587 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10508587 | pubmed:pagination | 987-9 | lld:pubmed |
| pubmed-article:10508587 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:10508587 | pubmed:meshHeading | pubmed-meshheading:10508587... | lld:pubmed |
| pubmed-article:10508587 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10508587 | pubmed:articleTitle | Evolutionary rate of a gene affected by chromosomal position. | lld:pubmed |
| pubmed-article:10508587 | pubmed:affiliation | Section of Gene Function and Regulation Chester Beatty Laboratories Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, UK. | lld:pubmed |
| pubmed-article:10508587 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10508587 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:10508587 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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