| pubmed-article:10508246 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10508246 | lifeskim:mentions | umls-concept:C0032556 | lld:lifeskim |
| pubmed-article:10508246 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:10508246 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:10508246 | lifeskim:mentions | umls-concept:C0028623 | lld:lifeskim |
| pubmed-article:10508246 | lifeskim:mentions | umls-concept:C0003343 | lld:lifeskim |
| pubmed-article:10508246 | lifeskim:mentions | umls-concept:C0003261 | lld:lifeskim |
| pubmed-article:10508246 | lifeskim:mentions | umls-concept:C1853126 | lld:lifeskim |
| pubmed-article:10508246 | lifeskim:mentions | umls-concept:C0282056 | lld:lifeskim |
| pubmed-article:10508246 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:10508246 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:10508246 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:10508246 | pubmed:dateCreated | 1999-10-26 | lld:pubmed |
| pubmed-article:10508246 | pubmed:abstractText | We have previously demonstrated that in vivo expression of the polyomavirus DNA-binding T-antigen initiated production of IgG antibodies to T-antigen and to DNA, but not to a panel of autoantigens not related to nucleosomes, indicating an antigen-selective T cell-dependent B cell response. In this study, we demonstrate that CD4-positive T cells from both normal and systemic lupus erythematosus (SLE) patients readily proliferate in response to pure T-antigen, and also to T-antigen in complex with nucleosomes. T-antigen-specific T cell lines from both normal individuals and SLE patients proliferate in response to nucleosome-T-antigen complexes, but not to nucleosomes or histones. B cells co-cultured with T-antigen-specific T cells and stimulated with nucleosome-T-antigen complexes produce anti-T-antigen and anti-DNA antibodies, indicating that such CD4-positive T cells have the potential to interact with B cells specific for individual components of nucleosome-T-antigen complexes. Thus, a non-self DNA-binding protein like polyomavirus T-antigen may initiate and maintain an antibody response to DNA when T-antigen is actively expressed. | lld:pubmed |
| pubmed-article:10508246 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10508246 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10508246 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10508246 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10508246 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10508246 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10508246 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10508246 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10508246 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:10508246 | pubmed:issn | 0014-2980 | lld:pubmed |
| pubmed-article:10508246 | pubmed:author | pubmed-author:RekvigO POP | lld:pubmed |
| pubmed-article:10508246 | pubmed:author | pubmed-author:MoensUU | lld:pubmed |
| pubmed-article:10508246 | pubmed:author | pubmed-author:AndreassenKK | lld:pubmed |
| pubmed-article:10508246 | pubmed:author | pubmed-author:BredholtGG | lld:pubmed |
| pubmed-article:10508246 | pubmed:author | pubmed-author:BendiksenSS | lld:pubmed |
| pubmed-article:10508246 | pubmed:author | pubmed-author:KauricGG | lld:pubmed |
| pubmed-article:10508246 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10508246 | pubmed:volume | 29 | lld:pubmed |
| pubmed-article:10508246 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10508246 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10508246 | pubmed:pagination | 2715-28 | lld:pubmed |
| pubmed-article:10508246 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:10508246 | pubmed:meshHeading | pubmed-meshheading:10508246... | lld:pubmed |
| pubmed-article:10508246 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10508246 | pubmed:articleTitle | T cell lines specific for polyomavirus T-antigen recognize T-antigen complexed with nucleosomes: a molecular basis for anti-DNA antibody production. | lld:pubmed |
| pubmed-article:10508246 | pubmed:affiliation | Department of Molecular Genetics Institute of Medical Biology, University of Tromso, Tromso, Norway. | lld:pubmed |
| pubmed-article:10508246 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10508246 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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