| pubmed-article:10506141 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10506141 | lifeskim:mentions | umls-concept:C1333336 | lld:lifeskim |
| pubmed-article:10506141 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:10506141 | lifeskim:mentions | umls-concept:C1333664 | lld:lifeskim |
| pubmed-article:10506141 | lifeskim:mentions | umls-concept:C0162493 | lld:lifeskim |
| pubmed-article:10506141 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:10506141 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:10506141 | pubmed:issue | 41 | lld:pubmed |
| pubmed-article:10506141 | pubmed:dateCreated | 1999-11-9 | lld:pubmed |
| pubmed-article:10506141 | pubmed:abstractText | In the endocrine pancreas, alpha-cell-specific expression of the glucagon gene is mediated by DNA-binding proteins that interact with the proximal G1 promoter element, which contains several AT-rich domains. The homeodomain transcription factors brain-4, pax-6, and cdx-2 have been shown to bind to these sites and to transactivate glucagon gene expression. In the present study, we investigated the interaction of cdx-2 and pax-6 with p300, a co-activator coupled to the basal transcription machinery. In transient transfection-expression experiments, we found that the transactivating effects of cdx-2 and pax-6 on the glucagon gene were greatly enhanced by the additional expression of p300. This enhancement was due to direct protein-protein interactions of both pax-6 and cdx-2 with the N-terminal C/H1 domain of p300. pax-6 and cdx-2 also directly interacted with one another at the protein level. pax-6, bound to its DNA recognition site in the glucagon G1 promoter element, tethered cdx-2 to the molecular complex of pax-6 and p300. Further, we found that the presence of cdx-2 enhanced the interaction of pax-6 with p300, thus establishing a molecular complex of transcription factors implicated in tissue-specific glucagon gene expression with the basal transcriptional machinery. | lld:pubmed |
| pubmed-article:10506141 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10506141 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10506141 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10506141 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10506141 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10506141 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10506141 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:10506141 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:10506141 | pubmed:author | pubmed-author:HussainM AMA | lld:pubmed |
| pubmed-article:10506141 | pubmed:author | pubmed-author:HabenerJ FJF | lld:pubmed |
| pubmed-article:10506141 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10506141 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:10506141 | pubmed:volume | 274 | lld:pubmed |
| pubmed-article:10506141 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10506141 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10506141 | pubmed:pagination | 28950-7 | lld:pubmed |
| pubmed-article:10506141 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:10506141 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10506141 | pubmed:articleTitle | Glucagon gene transcription activation mediated by synergistic interactions of pax-6 and cdx-2 with the p300 co-activator. | lld:pubmed |
| pubmed-article:10506141 | pubmed:affiliation | Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. | lld:pubmed |
| pubmed-article:10506141 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10506141 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10506141 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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