| pubmed-article:10500198 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10500198 | lifeskim:mentions | umls-concept:C0015576 | lld:lifeskim |
| pubmed-article:10500198 | lifeskim:mentions | umls-concept:C0021760 | lld:lifeskim |
| pubmed-article:10500198 | lifeskim:mentions | umls-concept:C0079189 | lld:lifeskim |
| pubmed-article:10500198 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:10500198 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:10500198 | pubmed:issue | 20 | lld:pubmed |
| pubmed-article:10500198 | pubmed:dateCreated | 1999-10-21 | lld:pubmed |
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| pubmed-article:10500198 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500198 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500198 | pubmed:abstractText | We have identified a cytokine of the IL-6 family and named it novel neurotrophin-1/B cell-stimulating factor-3 (NNT-1/BSF-3). NNT-1/BSF-3 cDNA was cloned from activated Jurkat human T cell lymphoma cells. Its sequence predicts a 225-aa protein with a 27-aa signal peptide, a molecular mass of 22 kDa in mature form, and the highest homology to cardiotrophin-1 and ciliary neurotrophic factor. The gene for NNT-1/BSF-3 is on chromosome 11q13. A murine equivalent to NNT-1/BSF-3 also was identified, which shows 96% homology to human NNT-1/BSF-3. NNT-1/BSF-3 mRNA is found mainly in lymph nodes and spleen. NNT-1/BSF-3 induces tyrosine phosphorylation of glycoprotein 130 (gp130), leukemia inhibitory factor receptor beta, and signal transducer and activator of transcription 3 in the SK-N-MC human neuroblastoma cells. NNT-1/BSF-3 shows activities typical of IL-6 family members. In vitro, it supports the survival of chicken embryo motor and sympathetic neurons. In mice, it induces serum amyloid A, potentiates the induction by IL-1 of corticosterone and IL-6, and causes body weight loss and B cell hyperplasia with serum IgG and IgM increase. NNT-1/BSF-3 is a gp130 activator with B-cell stimulating capability. | lld:pubmed |
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| pubmed-article:10500198 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10500198 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10500198 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10500198 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10500198 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10500198 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:10500198 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:10500198 | pubmed:author | pubmed-author:MannII | lld:pubmed |
| pubmed-article:10500198 | pubmed:author | pubmed-author:ElliottGG | lld:pubmed |
| pubmed-article:10500198 | pubmed:author | pubmed-author:GutMM | lld:pubmed |
| pubmed-article:10500198 | pubmed:author | pubmed-author:BooneTT | lld:pubmed |
| pubmed-article:10500198 | pubmed:author | pubmed-author:ScullySS | lld:pubmed |
| pubmed-article:10500198 | pubmed:author | pubmed-author:FreemanDD | lld:pubmed |
| pubmed-article:10500198 | pubmed:author | pubmed-author:ChangM SMS | lld:pubmed |
| pubmed-article:10500198 | pubmed:author | pubmed-author:SenaldiGG | lld:pubmed |
| pubmed-article:10500198 | pubmed:author | pubmed-author:VarnumB CBC | lld:pubmed |
| pubmed-article:10500198 | pubmed:author | pubmed-author:SimonetW SWS | lld:pubmed |
| pubmed-article:10500198 | pubmed:author | pubmed-author:LillAA | lld:pubmed |
| pubmed-article:10500198 | pubmed:author | pubmed-author:SarmientoUU | lld:pubmed |
| pubmed-article:10500198 | pubmed:author | pubmed-author:McNinchJJ | lld:pubmed |
| pubmed-article:10500198 | pubmed:author | pubmed-author:ShakleeC LCL | lld:pubmed |
| pubmed-article:10500198 | pubmed:author | pubmed-author:StarnesCC | lld:pubmed |
| pubmed-article:10500198 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10500198 | pubmed:day | 28 | lld:pubmed |
| pubmed-article:10500198 | pubmed:volume | 96 | lld:pubmed |
| pubmed-article:10500198 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10500198 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10500198 | pubmed:pagination | 11458-63 | lld:pubmed |
| pubmed-article:10500198 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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