| pubmed-article:10499377 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10499377 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:10499377 | lifeskim:mentions | umls-concept:C0079281 | lld:lifeskim |
| pubmed-article:10499377 | lifeskim:mentions | umls-concept:C0225336 | lld:lifeskim |
| pubmed-article:10499377 | lifeskim:mentions | umls-concept:C0010592 | lld:lifeskim |
| pubmed-article:10499377 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:10499377 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:10499377 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:10499377 | pubmed:dateCreated | 1999-11-15 | lld:pubmed |
| pubmed-article:10499377 | pubmed:abstractText | Cyclosporin A employed in treatment of organ allograft rejection, is associated with hypertension possibly due to endothelin-1. We studied transcriptional regulation of endothelin-1 by cyclosporin A in human endothelial cells using cell transfection experiments and reporter gene assays. Human umbilical vein endothelial cells were established expressing a fusion gene of the coding sequence of the firefly luciferase gene, placed under the control of the rat endothelin-1 promoter. Luciferase assays demonstrate 2.8-fold stimulation of the reporter gene by cyclosporin A (P < 0.01), and Northern blot analysis shows induction of prepro endothelin-1 mRNA. Transcription is tightly repressed in the absence of the immunosuppressant, its regulation occurs Ca(2+)-dependent. Lack of extra- or intracellular Ca2+ prevents cyclosporin A-dependent endothelin-1 gene transcription and mRNA induction. These data demonstrate transcriptional regulation of endothelin-1 over a range of several orders of magnitude in human umbilical vein endothelial cells by cyclosporin A via Ca(2+)-dependent mechanisms. They support the critical role of endothelin- in cyclosporin A-associated hypertension. | lld:pubmed |
| pubmed-article:10499377 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10499377 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10499377 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10499377 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10499377 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10499377 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10499377 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10499377 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10499377 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10499377 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10499377 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10499377 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10499377 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10499377 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:10499377 | pubmed:issn | 0014-2999 | lld:pubmed |
| pubmed-article:10499377 | pubmed:author | pubmed-author:WeberFF | lld:pubmed |
| pubmed-article:10499377 | pubmed:author | pubmed-author:BaldamusC ACA | lld:pubmed |
| pubmed-article:10499377 | pubmed:author | pubmed-author:MarsenT ATA | lld:pubmed |
| pubmed-article:10499377 | pubmed:author | pubmed-author:SuckauGG | lld:pubmed |
| pubmed-article:10499377 | pubmed:author | pubmed-author:EginkGG | lld:pubmed |
| pubmed-article:10499377 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10499377 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:10499377 | pubmed:volume | 379 | lld:pubmed |
| pubmed-article:10499377 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10499377 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10499377 | pubmed:pagination | 97-106 | lld:pubmed |
| pubmed-article:10499377 | pubmed:dateRevised | 2006-5-1 | lld:pubmed |
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| pubmed-article:10499377 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10499377 | pubmed:articleTitle | Cyclosporin A induces prepro endothelin-1 gene transcription in human endothelial cells. | lld:pubmed |
| pubmed-article:10499377 | pubmed:affiliation | Klinik IV für Innere Medizin, University of Cologne, Germany. tobias.marsen@uni-koeln.de | lld:pubmed |
| pubmed-article:10499377 | pubmed:publicationType | Journal Article | lld:pubmed |
