| pubmed-article:10496873 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10496873 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:10496873 | lifeskim:mentions | umls-concept:C0383327 | lld:lifeskim |
| pubmed-article:10496873 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:10496873 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:10496873 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:10496873 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:10496873 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:10496873 | lifeskim:mentions | umls-concept:C0439801 | lld:lifeskim |
| pubmed-article:10496873 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:10496873 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:10496873 | pubmed:dateCreated | 1999-10-14 | lld:pubmed |
| pubmed-article:10496873 | pubmed:abstractText | Optimal immune responses against an intracellular bacterial pathogen, such as Salmonella, involve the production of gamma interferon (IFN-gamma), which activates macrophages. It has recently been suggested that, interleukin-18 (IL-18), in addition to IL-12, contributes to the induction of IFN-gamma following infection. Given this hypothesis, an optimal host immune response against intracellular bacterial pathogens would include the induction of IL-18 secretion by macrophages due to Salmonella infection. We questioned whether Salmonella could induce macrophages to upregulate their expression of IL-18 mRNA and secretion of IL-18. With cultures of murine macrophages, we were surprised to find that infection by wild-type Salmonella dublin resulted in decreased expression of IL-18 mRNA and IL-18 secretion rather than an increase. Reduction of macrophage-derived IL-18 expression by wild-type Salmonella occurred early in the response, suggesting a direct effect. Furthermore, mice orally inoculated with wild-type Salmonella were shown to have reduced IL-18 mRNA expression at mucosal sites within hours postinoculation. Together these studies demonstrate Salmonella-induced reductions in IL-18 expression, suggesting that this intracellular pathogen may be capable of limiting a potentially protective immune response. | lld:pubmed |
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| pubmed-article:10496873 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:10496873 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10496873 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10496873 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:10496873 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:10496873 | pubmed:author | pubmed-author:BostK LKL | lld:pubmed |
| pubmed-article:10496873 | pubmed:author | pubmed-author:ElhofyAA | lld:pubmed |
| pubmed-article:10496873 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10496873 | pubmed:volume | 67 | lld:pubmed |
| pubmed-article:10496873 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10496873 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10496873 | pubmed:pagination | 5021-6 | lld:pubmed |
| pubmed-article:10496873 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:10496873 | pubmed:meshHeading | pubmed-meshheading:10496873... | lld:pubmed |
| pubmed-article:10496873 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10496873 | pubmed:articleTitle | Limited interleukin-18 response in Salmonella-infected murine macrophages and in Salmonella-infected mice. | lld:pubmed |
| pubmed-article:10496873 | pubmed:affiliation | Department of Biology, University of North Carolina-Charlotte, Charlotte, North Carolina 28223, USA. | lld:pubmed |
| pubmed-article:10496873 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10496873 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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