| pubmed-article:10493175 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10493175 | lifeskim:mentions | umls-concept:C0521009 | lld:lifeskim |
| pubmed-article:10493175 | lifeskim:mentions | umls-concept:C0023861 | lld:lifeskim |
| pubmed-article:10493175 | lifeskim:mentions | umls-concept:C0017355 | lld:lifeskim |
| pubmed-article:10493175 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:10493175 | lifeskim:mentions | umls-concept:C0178719 | lld:lifeskim |
| pubmed-article:10493175 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:10493175 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:10493175 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:10493175 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:10493175 | lifeskim:mentions | umls-concept:C0443288 | lld:lifeskim |
| pubmed-article:10493175 | lifeskim:mentions | umls-concept:C0450254 | lld:lifeskim |
| pubmed-article:10493175 | pubmed:issue | 2-3 | lld:pubmed |
| pubmed-article:10493175 | pubmed:dateCreated | 1999-12-14 | lld:pubmed |
| pubmed-article:10493175 | pubmed:abstractText | Studies of the murine immune response to infection with the intracellular bacterial pathogen Listeria monocytogenes have provided a wealth of information about innate and acquired immune defenses in the setting of an infectious disease. Our studies have focused on the MHC class I restricted, CD8+ T cell responses of Balb/c mice to L. monocytogenes infection. Four peptides that derive from proteins that L. monocytogenes secretes into the cytosol of infected cells are presented to cytotoxic T lymphocyte (CTL) by the H2-Kd major histocompatibility complex (MHC) class I molecule. We have found that bacterially secreted proteins are rapidly degraded in the host cell cytosol by proteasomes that utilize, at least in part, the N-end rule to determine the rate of degradation. The MHC class I antigen processing pathway is remarkably efficient at generating peptides that bind to MHC class I molecules. The magnitude of in vivo T cell responses, however, is influenced to only a small degree by the amount of antigen or the efficiency of antigen presentation. Measurements of in vivo T cell expansion following L. monocytogenes infection indicate that differences in the sizes of peptide-specific T cell responses are more likely owing to differences in the repertoire of naive T cells than to differences in peptide presentation. This notion is supported by our additional finding that dominant T cell populations express a more diverse T cell receptor (TCR) repertoire than do subdominant T cell populations. | lld:pubmed |
| pubmed-article:10493175 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10493175 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10493175 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10493175 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10493175 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10493175 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10493175 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10493175 | pubmed:issn | 0257-277X | lld:pubmed |
| pubmed-article:10493175 | pubmed:author | pubmed-author:MercadoRR | lld:pubmed |
| pubmed-article:10493175 | pubmed:author | pubmed-author:MarshallNN | lld:pubmed |
| pubmed-article:10493175 | pubmed:author | pubmed-author:BuschD HDH | lld:pubmed |
| pubmed-article:10493175 | pubmed:author | pubmed-author:PamerE GEG | lld:pubmed |
| pubmed-article:10493175 | pubmed:author | pubmed-author:AllenS ESE | lld:pubmed |
| pubmed-article:10493175 | pubmed:author | pubmed-author:FinelliAA | lld:pubmed |
| pubmed-article:10493175 | pubmed:author | pubmed-author:PilipII | lld:pubmed |
| pubmed-article:10493175 | pubmed:author | pubmed-author:KerksiekK MKM | lld:pubmed |
| pubmed-article:10493175 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10493175 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:10493175 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10493175 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10493175 | pubmed:pagination | 211-23 | lld:pubmed |
| pubmed-article:10493175 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:10493175 | pubmed:meshHeading | pubmed-meshheading:10493175... | lld:pubmed |
| pubmed-article:10493175 | pubmed:meshHeading | pubmed-meshheading:10493175... | lld:pubmed |
| pubmed-article:10493175 | pubmed:meshHeading | pubmed-meshheading:10493175... | lld:pubmed |
| pubmed-article:10493175 | pubmed:meshHeading | pubmed-meshheading:10493175... | lld:pubmed |
| pubmed-article:10493175 | pubmed:meshHeading | pubmed-meshheading:10493175... | lld:pubmed |
| pubmed-article:10493175 | pubmed:meshHeading | pubmed-meshheading:10493175... | lld:pubmed |
| pubmed-article:10493175 | pubmed:meshHeading | pubmed-meshheading:10493175... | lld:pubmed |
| pubmed-article:10493175 | pubmed:meshHeading | pubmed-meshheading:10493175... | lld:pubmed |
| pubmed-article:10493175 | pubmed:meshHeading | pubmed-meshheading:10493175... | lld:pubmed |
| pubmed-article:10493175 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10493175 | pubmed:articleTitle | MHC class I restricted T cell responses to Listeria monocytogenes, an intracellular bacterial pathogen. | lld:pubmed |
| pubmed-article:10493175 | pubmed:affiliation | Section of Infectious Diseases, Yale University School of Medicine, New Haven, CT 06520-8022, USA. | lld:pubmed |
| pubmed-article:10493175 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10493175 | pubmed:publicationType | Review | lld:pubmed |
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