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pubmed-article:10488701pubmed:abstractTextCD14 has been identified as a receptor for LPS and is present both in a membrane-bound and a soluble form. Membrane CD14 (mCD14) is predominantly expressed on monocytes, macrophages and granulocytes. The source of soluble CD14 (sCD14) is as yet unclear. Previous investigation using monocytes has shown that sCD14 can be derived either from the shedding of mCD14 or from direct secretion by monocytes. Whether the monocyte is the sole or even the major source of sCD14 is as yet uncertain. Clearance of LPS from the bloodstream is thought to be primarily mediated by the liver. Production of CD14 by hepatocytes would potentially provide a powerful mechanism by which the liver could clear LPS, and therefore we examined the ability of human hepatocytes to produce CD14.lld:pubmed
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pubmed-article:10488701pubmed:authorpubmed-author:NüsslerA KAKlld:pubmed
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pubmed-article:10488701pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:10488701pubmed:articleTitleCD14 expression and production by human hepatocytes.lld:pubmed
pubmed-article:10488701pubmed:affiliationDepartment of Medicine, University of Michigan, Ann Arbor 48109-0666, USA. gsu@umich-edulld:pubmed
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