| pubmed-article:10485457 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10485457 | lifeskim:mentions | umls-concept:C1420644 | lld:lifeskim |
| pubmed-article:10485457 | lifeskim:mentions | umls-concept:C1705000 | lld:lifeskim |
| pubmed-article:10485457 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:10485457 | lifeskim:mentions | umls-concept:C1527249 | lld:lifeskim |
| pubmed-article:10485457 | lifeskim:mentions | umls-concept:C0920269 | lld:lifeskim |
| pubmed-article:10485457 | lifeskim:mentions | umls-concept:C0079380 | lld:lifeskim |
| pubmed-article:10485457 | lifeskim:mentions | umls-concept:C0332183 | lld:lifeskim |
| pubmed-article:10485457 | pubmed:issue | 17 | lld:pubmed |
| pubmed-article:10485457 | pubmed:dateCreated | 1999-9-30 | lld:pubmed |
| pubmed-article:10485457 | pubmed:abstractText | About 15% of sporadic colorectal cancers show microsatellite instability (MSI) due to the inactivation of mismatch repair genes and are termed MSI-H tumors. In these tumors, frameshift mutations in coding repeats have been found within the TGFbeta-RII, BAX, and IGFRII genes that are probably involved in their progression. In the present work, we report frequent mutations in TCF-4, another target gene for instability. TCF-4 codes for a transcription factor that is a crucial member of the adenomatous polyposis coil (APC)/beta-catenin/T-cell factor (TCF) pathway. Fifty percent (4 of 8) of human MSI-H colorectal cell lines and 39% (19 of 49) of MSI-H colorectal primary tumors were found to have a 1-bp deletion in an (A)9 repeat within the coding region of this gene. In contrast, a frameshift mutation was found in only 1 of 56 non-MSI colorectal tumors and in none of 16 non-MSI colorectal cancer cell lines. These results suggest that TCF-4 frameshift mutations are selected for and play a role in colorectal MSI-H tumorigenesis. Depending on different reading frames due to alternatively spliced TCF-4 mRNA, the (A)9 repeat normally codes for several isoforms that could serve as modulators of TCF-4 transcriptional activity. The deletion of one nucleotide in this repeat could change TCF-4 transactivating properties by modifying the respective proportions of the different isoforms. | lld:pubmed |
| pubmed-article:10485457 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10485457 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10485457 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10485457 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10485457 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:10485457 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:10485457 | pubmed:author | pubmed-author:GayetJJ | lld:pubmed |
| pubmed-article:10485457 | pubmed:author | pubmed-author:ThomasGG | lld:pubmed |
| pubmed-article:10485457 | pubmed:author | pubmed-author:HamelinRR | lld:pubmed |
| pubmed-article:10485457 | pubmed:author | pubmed-author:DuvalAA | lld:pubmed |
| pubmed-article:10485457 | pubmed:author | pubmed-author:ZhowX RXR | lld:pubmed |
| pubmed-article:10485457 | pubmed:author | pubmed-author:IacopettaBB | lld:pubmed |
| pubmed-article:10485457 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10485457 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:10485457 | pubmed:volume | 59 | lld:pubmed |
| pubmed-article:10485457 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10485457 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10485457 | pubmed:pagination | 4213-5 | lld:pubmed |
| pubmed-article:10485457 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:10485457 | pubmed:meshHeading | pubmed-meshheading:10485457... | lld:pubmed |
| pubmed-article:10485457 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10485457 | pubmed:articleTitle | Frequent frameshift mutations of the TCF-4 gene in colorectal cancers with microsatellite instability. | lld:pubmed |
| pubmed-article:10485457 | pubmed:affiliation | INSERM U434-Centre d'Etude de Polymorphisme Humane, Paris, France. | lld:pubmed |
| pubmed-article:10485457 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10485457 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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