| pubmed-article:10484382 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10484382 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:10484382 | lifeskim:mentions | umls-concept:C0021368 | lld:lifeskim |
| pubmed-article:10484382 | lifeskim:mentions | umls-concept:C0699819 | lld:lifeskim |
| pubmed-article:10484382 | lifeskim:mentions | umls-concept:C0078056 | lld:lifeskim |
| pubmed-article:10484382 | lifeskim:mentions | umls-concept:C1533698 | lld:lifeskim |
| pubmed-article:10484382 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:10484382 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:10484382 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:10484382 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:10484382 | pubmed:issue | 3 Pt 1 | lld:pubmed |
| pubmed-article:10484382 | pubmed:dateCreated | 1999-10-28 | lld:pubmed |
| pubmed-article:10484382 | pubmed:abstractText | The objectives of this study were to assess the role of the inducible isoform of nitric oxide synthase (iNOS) on vascular cell adhesion molecule 1 (VCAM-1) expression in vivo in an acute model of inflammation induced in iNOS-deficient (iNOS-/-) mice and compare these data to those obtained by pharmacological inhibition of iNOS in a CD4+ T lymphocyte-dependent model of chronic colitis. VCAM-1 expression was quantified in vivo using the dual radiolabel monoclonal antibody technique. We found that intraperitoneal injection of 10 microg/kg tumor necrosis factor-alpha (TNF-alpha) enhanced VCAM-1 expression by approximately twofold in the colon, cecum, and stomach but not small intestine in iNOS-/- mice compared with TNF-alpha-injected wild-type mice. Injection of wild-type mice with 25 microg/kg TNF-alpha further enhanced VCAM-1 expression by approximately twofold compared with wild-type mice injected with 10 microg/kg TNF-alpha; however, VCAM-1 expression was not further enhanced in any gastrointestinal organ system in iNOS-/- mice. In a second series of experiments, we found that continuous inhibition of iNOS using oral administration of NG-iminoethyl-L-lysine did not alter the enhanced levels of VCAM-1 expression in the colon nor did it alter the severity of colonic inflammation in SCID mice reconstituted with CD4+, CD45RB(high) T cells. We conclude that iNOS may regulate VCAM-1 expression in acute inflammation; however, this effect is modest and tissue specific and occurs only when VCAM-1 expression is submaximal. iNOS does not appear to modulate VCAM-1 expression in an immune model of chronic colitis. | lld:pubmed |
| pubmed-article:10484382 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10484382 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10484382 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10484382 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10484382 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10484382 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10484382 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10484382 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10484382 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10484382 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10484382 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10484382 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:10484382 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:10484382 | pubmed:author | pubmed-author:GrangerD NDN | lld:pubmed |
| pubmed-article:10484382 | pubmed:author | pubmed-author:GrayLL | lld:pubmed |
| pubmed-article:10484382 | pubmed:author | pubmed-author:GrishamM BMB | lld:pubmed |
| pubmed-article:10484382 | pubmed:author | pubmed-author:KawachiSS | lld:pubmed |
| pubmed-article:10484382 | pubmed:author | pubmed-author:CockrellAA | lld:pubmed |
| pubmed-article:10484382 | pubmed:author | pubmed-author:van der... | lld:pubmed |
| pubmed-article:10484382 | pubmed:author | pubmed-author:LarouxF SFS | lld:pubmed |
| pubmed-article:10484382 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10484382 | pubmed:volume | 277 | lld:pubmed |
| pubmed-article:10484382 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10484382 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10484382 | pubmed:pagination | G572-6 | lld:pubmed |
| pubmed-article:10484382 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:10484382 | pubmed:meshHeading | pubmed-meshheading:10484382... | lld:pubmed |
| pubmed-article:10484382 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10484382 | pubmed:articleTitle | Role of inducible nitric oxide synthase in the regulation of VCAM-1 expression in gut inflammation. | lld:pubmed |
| pubmed-article:10484382 | pubmed:affiliation | Department of Molecular and Cellular Physiology, Louisiana State University Medical Center, Shreveport, Louisiana 71130, USA. | lld:pubmed |
| pubmed-article:10484382 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10484382 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10484382 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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