| pubmed-article:10482640 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10482640 | lifeskim:mentions | umls-concept:C0023418 | lld:lifeskim |
| pubmed-article:10482640 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:10482640 | lifeskim:mentions | umls-concept:C0013203 | lld:lifeskim |
| pubmed-article:10482640 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:10482640 | lifeskim:mentions | umls-concept:C0035380 | lld:lifeskim |
| pubmed-article:10482640 | lifeskim:mentions | umls-concept:C1549772 | lld:lifeskim |
| pubmed-article:10482640 | lifeskim:mentions | umls-concept:C1548566 | lld:lifeskim |
| pubmed-article:10482640 | lifeskim:mentions | umls-concept:C1548394 | lld:lifeskim |
| pubmed-article:10482640 | lifeskim:mentions | umls-concept:C0442335 | lld:lifeskim |
| pubmed-article:10482640 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:10482640 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:10482640 | pubmed:dateCreated | 1999-10-12 | lld:pubmed |
| pubmed-article:10482640 | pubmed:abstractText | Expression of the selectable drug resistance gene in retroviral vectors used for gene therapy can lead to a decreased expression of the gene of interest and may induce a host immune response, resulting in a decreased efficiency of gene therapy. In this study, we demonstrate that high-frequency deletion of direct repeats, an inherent property of reverse transcriptases, can be used to efficiently excise the drug resistance gene during reverse transcription. One retroviral vector containing a direct repeat deleted the neomycin resistance expression cassette during a single replication cycle at >99% efficiency. | lld:pubmed |
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| pubmed-article:10482640 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10482640 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10482640 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10482640 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10482640 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:10482640 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:10482640 | pubmed:author | pubmed-author:PathakV KVK | lld:pubmed |
| pubmed-article:10482640 | pubmed:author | pubmed-author:DelviksK AKA | lld:pubmed |
| pubmed-article:10482640 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10482640 | pubmed:volume | 73 | lld:pubmed |
| pubmed-article:10482640 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10482640 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10482640 | pubmed:pagination | 8837-42 | lld:pubmed |
| pubmed-article:10482640 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:10482640 | pubmed:meshHeading | pubmed-meshheading:10482640... | lld:pubmed |
| pubmed-article:10482640 | pubmed:meshHeading | pubmed-meshheading:10482640... | lld:pubmed |
| pubmed-article:10482640 | pubmed:meshHeading | pubmed-meshheading:10482640... | lld:pubmed |
| pubmed-article:10482640 | pubmed:meshHeading | pubmed-meshheading:10482640... | lld:pubmed |
| pubmed-article:10482640 | pubmed:meshHeading | pubmed-meshheading:10482640... | lld:pubmed |
| pubmed-article:10482640 | pubmed:meshHeading | pubmed-meshheading:10482640... | lld:pubmed |
| pubmed-article:10482640 | pubmed:meshHeading | pubmed-meshheading:10482640... | lld:pubmed |
| pubmed-article:10482640 | pubmed:meshHeading | pubmed-meshheading:10482640... | lld:pubmed |
| pubmed-article:10482640 | pubmed:meshHeading | pubmed-meshheading:10482640... | lld:pubmed |
| pubmed-article:10482640 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10482640 | pubmed:articleTitle | Development of murine leukemia virus-based self-activating vectors that efficiently delete the selectable drug resistance gene during reverse transcription. | lld:pubmed |
| pubmed-article:10482640 | pubmed:affiliation | Department of Genetics and Developmental Biology, West Virginia University, Morgantown, West Virginia 26506, USA. | lld:pubmed |
| pubmed-article:10482640 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10482640 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10482640 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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