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pubmed-article:10482449pubmed:abstractTextIt has been suggested that the FGF-2 binding site on heparan sulfate chains is a trisulfated pentasaccharide containing three hexuronic acid units. The configuration at C-5 of two of them being undetermined, we have synthesized the four possible pentasaccharides, and have evaluated their FGF-2 binding affinity through in vitro biological assays. The pentasaccharide containing L-iduronic acid as the sole hexuronic acid showed higher affinity for FGF-2 than the other pentasaccharides, where one hexuronic acid unit at least is D-glucuronic acid.lld:pubmed
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pubmed-article:10482449pubmed:articleTitleA synthetic heparan sulfate pentasaccharide, exclusively containing L-iduronic acid, displays higher affinity for FGF-2 than its D-glucuronic acid-containing isomers.lld:pubmed
pubmed-article:10482449pubmed:affiliationEcole Normale Supérieure, Département de Chimie, Associé au CNRS, Paris, France.lld:pubmed
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pubmed-article:10482449pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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