Linked Life Data

10481118

Source:http://linkedlifedata.com/resource/pubmed/id/10481118

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:10481118rdf:typepubmed:Citationlld:pubmed
pubmed-article:10481118lifeskim:mentionsumls-concept:C0030705lld:lifeskim
pubmed-article:10481118lifeskim:mentionsumls-concept:C0178784lld:lifeskim
pubmed-article:10481118lifeskim:mentionsumls-concept:C0021853lld:lifeskim
pubmed-article:10481118lifeskim:mentionsumls-concept:C0001339lld:lifeskim
pubmed-article:10481118lifeskim:mentionsumls-concept:C0376618lld:lifeskim
pubmed-article:10481118lifeskim:mentionsumls-concept:C0026565lld:lifeskim
pubmed-article:10481118lifeskim:mentionsumls-concept:C0205082lld:lifeskim
pubmed-article:10481118lifeskim:mentionsumls-concept:C0442805lld:lifeskim
pubmed-article:10481118lifeskim:mentionsumls-concept:C0231174lld:lifeskim
pubmed-article:10481118lifeskim:mentionsumls-concept:C0031164lld:lifeskim
pubmed-article:10481118lifeskim:mentionsumls-concept:C1707520lld:lifeskim
pubmed-article:10481118pubmed:issue3lld:pubmed
pubmed-article:10481118pubmed:dateCreated2000-5-10lld:pubmed
pubmed-article:10481118pubmed:abstractTextSepsis accounts for 80% of deaths from acute pancreatitis. This study aimed to investigate early changes in intestinal permeability in patients with acute pancreatitis, and to correlate these changes with subsequent disease severity and endotoxemia. The renal excretion of enterally administered polyethylene glycol (PEG) 3350 and PEG 400 was measured within 72 hours of onset of acute pancreatitis to determine intestinal permeability. Severity was assessed on the basis of APACHE II scores and C-reactive protein measurements. Serum endotoxin and antiendotoxin antibodies were measured on admission. Eight-five patients with acute pancreatitis (mild in 56, severe in 29) and 25 healthy control subjects were studied. Urinary excretion of PEG 3350 (median) was significantly greater in patients who had severe attacks (0.61%) compared to those with mild disease (0.09%) and health control subjects (0.12%) (P <0. 0001), as was the permeability index (PEG 3350/400 excretion) (P <0. 00001). The permeability index was significantly greater in patients who subsequently developed multiple organ system failure and/or died compared with other severe cases (0.16 vs. 0.04) (P = 0.0005). The excretion of PEG 3350 correlated strongly with endotoxemia (r = 0.8; P = 0.002). Early increased intestinal permeability may play an important role in the pathophysiology of severe acute pancreatitis. Therapies that aim to restore intestinal barrier function may improve outcome.lld:pubmed
pubmed-article:10481118pubmed:languageenglld:pubmed
pubmed-article:10481118pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10481118pubmed:citationSubsetIMlld:pubmed
pubmed-article:10481118pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10481118pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10481118pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10481118pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10481118pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10481118pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10481118pubmed:statusMEDLINElld:pubmed
pubmed-article:10481118pubmed:issn1091-255Xlld:pubmed
pubmed-article:10481118pubmed:authorpubmed-author:McMahonM JMJlld:pubmed
pubmed-article:10481118pubmed:authorpubmed-author:LOEBM BMBlld:pubmed
pubmed-article:10481118pubmed:authorpubmed-author:BarclayG RGRlld:pubmed
pubmed-article:10481118pubmed:authorpubmed-author:MartinI GIGlld:pubmed
pubmed-article:10481118pubmed:authorpubmed-author:LarvinMMlld:pubmed
pubmed-article:10481118pubmed:authorpubmed-author:AmmoriB JBJlld:pubmed
pubmed-article:10481118pubmed:authorpubmed-author:LeederP CPClld:pubmed
pubmed-article:10481118pubmed:issnTypePrintlld:pubmed
pubmed-article:10481118pubmed:volume3lld:pubmed
pubmed-article:10481118pubmed:ownerNLMlld:pubmed
pubmed-article:10481118pubmed:authorsCompleteYlld:pubmed
pubmed-article:10481118pubmed:pagination252-62lld:pubmed
pubmed-article:10481118pubmed:dateRevised2006-11-15lld:pubmed
pubmed-article:10481118pubmed:meshHeadingpubmed-meshheading:10481118...lld:pubmed
pubmed-article:10481118pubmed:meshHeadingpubmed-meshheading:10481118...lld:pubmed
pubmed-article:10481118pubmed:meshHeadingpubmed-meshheading:10481118...lld:pubmed
pubmed-article:10481118pubmed:meshHeadingpubmed-meshheading:10481118...lld:pubmed
pubmed-article:10481118pubmed:meshHeadingpubmed-meshheading:10481118...lld:pubmed
pubmed-article:10481118pubmed:meshHeadingpubmed-meshheading:10481118...lld:pubmed
pubmed-article:10481118pubmed:meshHeadingpubmed-meshheading:10481118...lld:pubmed
pubmed-article:10481118pubmed:meshHeadingpubmed-meshheading:10481118...lld:pubmed
pubmed-article:10481118pubmed:meshHeadingpubmed-meshheading:10481118...lld:pubmed
pubmed-article:10481118pubmed:meshHeadingpubmed-meshheading:10481118...lld:pubmed
pubmed-article:10481118pubmed:meshHeadingpubmed-meshheading:10481118...lld:pubmed
pubmed-article:10481118pubmed:meshHeadingpubmed-meshheading:10481118...lld:pubmed
pubmed-article:10481118pubmed:meshHeadingpubmed-meshheading:10481118...lld:pubmed
pubmed-article:10481118pubmed:meshHeadingpubmed-meshheading:10481118...lld:pubmed
pubmed-article:10481118pubmed:meshHeadingpubmed-meshheading:10481118...lld:pubmed
pubmed-article:10481118pubmed:meshHeadingpubmed-meshheading:10481118...lld:pubmed
pubmed-article:10481118pubmed:meshHeadingpubmed-meshheading:10481118...lld:pubmed
pubmed-article:10481118pubmed:meshHeadingpubmed-meshheading:10481118...lld:pubmed
pubmed-article:10481118pubmed:meshHeadingpubmed-meshheading:10481118...lld:pubmed
pubmed-article:10481118pubmed:meshHeadingpubmed-meshheading:10481118...lld:pubmed
pubmed-article:10481118pubmed:meshHeadingpubmed-meshheading:10481118...lld:pubmed
pubmed-article:10481118pubmed:meshHeadingpubmed-meshheading:10481118...lld:pubmed
pubmed-article:10481118pubmed:meshHeadingpubmed-meshheading:10481118...lld:pubmed
pubmed-article:10481118pubmed:meshHeadingpubmed-meshheading:10481118...lld:pubmed
pubmed-article:10481118pubmed:meshHeadingpubmed-meshheading:10481118...lld:pubmed
pubmed-article:10481118pubmed:articleTitleEarly increase in intestinal permeability in patients with severe acute pancreatitis: correlation with endotoxemia, organ failure, and mortality.lld:pubmed
pubmed-article:10481118pubmed:affiliationAcademic Surgical Unit, Division of Surgery, The University of Leeds and Centre for Digestive Diseases, The General Infirmary at Leeds, UK.lld:pubmed
pubmed-article:10481118pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:10481118pubmed:publicationTypeComparative Studylld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10481118lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10481118lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10481118lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10481118lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10481118lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10481118lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10481118lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10481118lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10481118lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10481118lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10481118lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10481118lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10481118lld:pubmed