| pubmed-article:10480893 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10480893 | lifeskim:mentions | umls-concept:C0525013 | lld:lifeskim |
| pubmed-article:10480893 | lifeskim:mentions | umls-concept:C0040624 | lld:lifeskim |
| pubmed-article:10480893 | lifeskim:mentions | umls-concept:C0005221 | lld:lifeskim |
| pubmed-article:10480893 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:10480893 | pubmed:issue | 38 | lld:pubmed |
| pubmed-article:10480893 | pubmed:dateCreated | 1999-10-13 | lld:pubmed |
| pubmed-article:10480893 | pubmed:abstractText | Four erythroid-specific DNase I-hypersensitive sites at the 5'-end of the beta-globin locus confer high-level transcription to the beta-globin genes. To identify coactivators that mediate long-range transactivation by this locus control region (LCR), we assessed the influence of E1A, an inhibitor of the CBP/p300 histone acetylase, on LCR function. E1A strongly inhibited transactivation of Agamma- and beta-globin promoters by the HS2, HS2-HS3, and HS1-HS4 subregions of the LCR in human K562 and mouse erythroleukemia cells. Short- and long-range transactivation mediated by the LCR were equally sensitive to E1A. The E1A sensitivity was apparent in transient and stable transfection assays, and E1A inhibited expression of the endogenous gamma-globin genes. Only sites for NF-E2 within HS2 were required for E1A sensitivity in K562 cells, and E1A abolished transactivation mediated by the activation domain of NF-E2. E1A mutants defective in CBP/p300 binding only weakly inhibited HS2-mediated transactivation, whereas a mutant defective in retinoblastoma protein binding strongly inhibited transactivation. Expression of CBP/p300 potentiated HS2-mediated transactivation. Moreover, expression of GAL4-CBP strongly increased transactivation of a reporter containing HS2 with a GAL4 site substituted for the NF-E2 sites. Thus, we propose that a CBP/p300-containing coactivator complex is the E1A-sensitive factor important for LCR function. | lld:pubmed |
| pubmed-article:10480893 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10480893 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10480893 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10480893 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10480893 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10480893 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10480893 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10480893 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10480893 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10480893 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10480893 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10480893 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10480893 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10480893 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10480893 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10480893 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10480893 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10480893 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10480893 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10480893 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10480893 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10480893 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:10480893 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:10480893 | pubmed:author | pubmed-author:JohnsonKK | lld:pubmed |
| pubmed-article:10480893 | pubmed:author | pubmed-author:BresnickE HEH | lld:pubmed |
| pubmed-article:10480893 | pubmed:author | pubmed-author:ZaboikinaT... | lld:pubmed |
| pubmed-article:10480893 | pubmed:author | pubmed-author:ForsbergE CEC | lld:pubmed |
| pubmed-article:10480893 | pubmed:author | pubmed-author:MosserE AEA | lld:pubmed |
| pubmed-article:10480893 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10480893 | pubmed:day | 17 | lld:pubmed |
| pubmed-article:10480893 | pubmed:volume | 274 | lld:pubmed |
| pubmed-article:10480893 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10480893 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10480893 | pubmed:pagination | 26850-9 | lld:pubmed |
| pubmed-article:10480893 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:10480893 | pubmed:meshHeading | pubmed-meshheading:10480893... | lld:pubmed |
| pubmed-article:10480893 | pubmed:meshHeading | pubmed-meshheading:10480893... | lld:pubmed |
| pubmed-article:10480893 | pubmed:meshHeading | pubmed-meshheading:10480893... | lld:pubmed |
| pubmed-article:10480893 | pubmed:meshHeading | pubmed-meshheading:10480893... | lld:pubmed |
| pubmed-article:10480893 | pubmed:meshHeading | pubmed-meshheading:10480893... | lld:pubmed |
| pubmed-article:10480893 | pubmed:meshHeading | pubmed-meshheading:10480893... | lld:pubmed |
| pubmed-article:10480893 | pubmed:meshHeading | pubmed-meshheading:10480893... | lld:pubmed |
| pubmed-article:10480893 | pubmed:meshHeading | pubmed-meshheading:10480893... | lld:pubmed |
| pubmed-article:10480893 | pubmed:meshHeading | pubmed-meshheading:10480893... | lld:pubmed |
| pubmed-article:10480893 | pubmed:meshHeading | pubmed-meshheading:10480893... | lld:pubmed |
| pubmed-article:10480893 | pubmed:meshHeading | pubmed-meshheading:10480893... | lld:pubmed |
| pubmed-article:10480893 | pubmed:meshHeading | pubmed-meshheading:10480893... | lld:pubmed |
| pubmed-article:10480893 | pubmed:meshHeading | pubmed-meshheading:10480893... | lld:pubmed |
| pubmed-article:10480893 | pubmed:meshHeading | pubmed-meshheading:10480893... | lld:pubmed |
| pubmed-article:10480893 | pubmed:meshHeading | pubmed-meshheading:10480893... | lld:pubmed |
| pubmed-article:10480893 | pubmed:meshHeading | pubmed-meshheading:10480893... | lld:pubmed |
| pubmed-article:10480893 | pubmed:meshHeading | pubmed-meshheading:10480893... | lld:pubmed |
| pubmed-article:10480893 | pubmed:meshHeading | pubmed-meshheading:10480893... | lld:pubmed |
| pubmed-article:10480893 | pubmed:meshHeading | pubmed-meshheading:10480893... | lld:pubmed |
| pubmed-article:10480893 | pubmed:meshHeading | pubmed-meshheading:10480893... | lld:pubmed |
| pubmed-article:10480893 | pubmed:meshHeading | pubmed-meshheading:10480893... | lld:pubmed |
| pubmed-article:10480893 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10480893 | pubmed:articleTitle | Requirement of an E1A-sensitive coactivator for long-range transactivation by the beta-globin locus control region. | lld:pubmed |
| pubmed-article:10480893 | pubmed:affiliation | Department of Pharmacology, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA. | lld:pubmed |
| pubmed-article:10480893 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10480893 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10480893 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10480893 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10480893 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10480893 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10480893 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10480893 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10480893 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10480893 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10480893 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10480893 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10480893 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10480893 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10480893 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10480893 | lld:pubmed |
