| pubmed-article:10480205 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10480205 | lifeskim:mentions | umls-concept:C0008059 | lld:lifeskim |
| pubmed-article:10480205 | lifeskim:mentions | umls-concept:C0238598 | lld:lifeskim |
| pubmed-article:10480205 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:10480205 | lifeskim:mentions | umls-concept:C0007789 | lld:lifeskim |
| pubmed-article:10480205 | lifeskim:mentions | umls-concept:C0001554 | lld:lifeskim |
| pubmed-article:10480205 | lifeskim:mentions | umls-concept:C0013072 | lld:lifeskim |
| pubmed-article:10480205 | lifeskim:mentions | umls-concept:C0034656 | lld:lifeskim |
| pubmed-article:10480205 | lifeskim:mentions | umls-concept:C0575081 | lld:lifeskim |
| pubmed-article:10480205 | lifeskim:mentions | umls-concept:C0231687 | lld:lifeskim |
| pubmed-article:10480205 | lifeskim:mentions | umls-concept:C0006050 | lld:lifeskim |
| pubmed-article:10480205 | lifeskim:mentions | umls-concept:C1273870 | lld:lifeskim |
| pubmed-article:10480205 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:10480205 | pubmed:dateCreated | 1999-11-4 | lld:pubmed |
| pubmed-article:10480205 | pubmed:abstractText | The present study was performed to assess dose-response relationships of local botulinum toxin A (BtxA) treatment in children and teenagers with spastic gait due to cerebral palsy (CP) in a randomized, double-blind study employing a "high-dose" (200 units Botox per leg) and a "low-dose" (100 units Botox per leg) treatment arm in 33 patients with CP. Response parameters included changes in muscle tone assessed by the Ashworth scale at knee joint, range-of-motion (ROM) measurements at knee and ankle joint, objective analysis of longitudinal gait parameters as well as subjective assessments of improvement. Patients in the "high-dose" arm received 40-80 units Botox/muscle versus 20-40 units Botox/muscle in the "low-dose" group. Patients in both treatment arms showed significant improvement of Ashworth score (p<0.001) and ROM (p<0.01), while gait analysis revealed significant increase in gait velocity (p<0.01) and stride-length (p<0.001) over baseline. Subjects in the "high-dose" group showed significantly greater improvement on objective response measurements compared to "low-dose" patients. Also, children aged 7 years or less had greater functional benefit compared to the subgroup of patients older than 7 years. Incidence and severity of side-effects were similar in both treatment groups. The present study demonstrated dose-dependent functional improvement of dynamic deformities and spastic gait pattern in children and young adults with CP treated with local injections of botulinum toxin. A dose of 200 units Botox per leg distributed to 4 or 5 muscle bellies per leg is superior compared to 100 units Botox per leg without significantly affecting the risk of side-effects. | lld:pubmed |
| pubmed-article:10480205 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10480205 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10480205 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10480205 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10480205 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10480205 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:10480205 | pubmed:issn | 0174-304X | lld:pubmed |
| pubmed-article:10480205 | pubmed:author | pubmed-author:MüllerJJ | lld:pubmed |
| pubmed-article:10480205 | pubmed:author | pubmed-author:PoeweWW | lld:pubmed |
| pubmed-article:10480205 | pubmed:author | pubmed-author:DoleMM | lld:pubmed |
| pubmed-article:10480205 | pubmed:author | pubmed-author:HeinenFF | lld:pubmed |
| pubmed-article:10480205 | pubmed:author | pubmed-author:WisselJJ | lld:pubmed |
| pubmed-article:10480205 | pubmed:author | pubmed-author:EbersbachGG | lld:pubmed |
| pubmed-article:10480205 | pubmed:author | pubmed-author:SchenkerGG | lld:pubmed |
| pubmed-article:10480205 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10480205 | pubmed:volume | 30 | lld:pubmed |
| pubmed-article:10480205 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10480205 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10480205 | pubmed:pagination | 120-4 | lld:pubmed |
| pubmed-article:10480205 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:10480205 | pubmed:meshHeading | pubmed-meshheading:10480205... | lld:pubmed |
| pubmed-article:10480205 | pubmed:meshHeading | pubmed-meshheading:10480205... | lld:pubmed |
| pubmed-article:10480205 | pubmed:meshHeading | pubmed-meshheading:10480205... | lld:pubmed |
| pubmed-article:10480205 | pubmed:meshHeading | pubmed-meshheading:10480205... | lld:pubmed |
| pubmed-article:10480205 | pubmed:meshHeading | pubmed-meshheading:10480205... | lld:pubmed |
| pubmed-article:10480205 | pubmed:meshHeading | pubmed-meshheading:10480205... | lld:pubmed |
| pubmed-article:10480205 | pubmed:meshHeading | pubmed-meshheading:10480205... | lld:pubmed |
| pubmed-article:10480205 | pubmed:meshHeading | pubmed-meshheading:10480205... | lld:pubmed |
| pubmed-article:10480205 | pubmed:meshHeading | pubmed-meshheading:10480205... | lld:pubmed |
| pubmed-article:10480205 | pubmed:meshHeading | pubmed-meshheading:10480205... | lld:pubmed |
| pubmed-article:10480205 | pubmed:meshHeading | pubmed-meshheading:10480205... | lld:pubmed |
| pubmed-article:10480205 | pubmed:meshHeading | pubmed-meshheading:10480205... | lld:pubmed |
| pubmed-article:10480205 | pubmed:meshHeading | pubmed-meshheading:10480205... | lld:pubmed |
| pubmed-article:10480205 | pubmed:meshHeading | pubmed-meshheading:10480205... | lld:pubmed |
| pubmed-article:10480205 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10480205 | pubmed:articleTitle | Botulinum toxin A in the management of spastic gait disorders in children and young adults with cerebral palsy: a randomized, double-blind study of "high-dose" versus "low-dose" treatment. | lld:pubmed |
| pubmed-article:10480205 | pubmed:affiliation | Department of Neurology, Universitätsklinik Innsbruck, Austria. | lld:pubmed |
| pubmed-article:10480205 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10480205 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:10480205 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:10480205 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
| pubmed-article:10480205 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10480205 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10480205 | lld:pubmed |
